VASICINE

(R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol; Vasicin; (3R)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol; Peganine;

 VASICINE

 

PRODUCT IDENTIFICATION

CAS RN

6159-55-3

EINECS RN

228-180-8

FORMULA

C11H12N2O

MOLE WEIGHT

188.23

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to yellow powder

MELTING POINT

209 - 211 C (Decomposes)

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

pH

 

VAPOR DENSITY

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

DECOMPOSITION PRODUCTS

Carbon oxides. nitrogen oxides, ammonia

POLYMERIZATION Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

SAFETY

HAZARD NOTES

Toxic by inhalation, in contact with skin and if swallowed

EYE

 

SKIN

 

INGESTION

 

INHALATION

 

CHRONIC

 

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 
HAZARD CLASS

 

PACKING GROUP

 

HAZARD SYMBOL

T

RISK PHRASES

23/24/25

SAFETY PHRASES

28-36/37/39-45

 

EXTERNAL LINKS & GENERAL INFORMATION

The pharmacological activities of vasicine and vasicinone are well known. Recent investigations on vasicine showed bronchodilatory activity comparable to theophylline, both in vitro and in vivo. Both the alkaloids in combination showed pronounced bronchodilatory activity. Vasicine also exhibits strong respiratory stimulant activity. There has also been a report of thrombopoetic4 (platelet-increasing) activity with vasicine. Uterine stimulant activity and moderate hypotensive activity of the alkaloids have been observed. (http://thestar.com.my/)

Adulsa(Adhathoda vasica), also known as vasaka, is distributed all over the plains of India & in lower Himalayan ranges, ascending to a height of 1.5 m. The plant has been recommended by Ayurvedic physicians for the management of various types of respiratory disorders. It possesses potent bronchodilatory, expectorant, anti-spasmodic and anti-septic properties. It also possesses significant antimicrobial activity against gingival inflammation and pyorrhea. It has also shown Uterine stimulant activity, moderate hypotensive activity and thrombopoeitic activity. The leaves of the plant contain two major alkaloids called vasicine and vasicinone which are responsible for its medicinal properties. The bronchodilatory & expectorant properties of the leaves are attributed to vasicine. Recent investigations on vasicine showed bronchodilatory activity comparable to theophylline, which is a methylxanthine drug used in therapy for respiratory diseases such as COPD or asthma. (http://www.associatedcontent.com/)

The pharmacological action of the alkaloids in Adhatoda vasica were studied as early as 1959. Amin and Mehta studied vasicinone for its action on guinea pig trachea and perfused lung and on intact guinea pigs. Vasicinone antagonized histamineinduced constriction, but was less effective than adrenaline. A quinazol4one ring is found in vasicine and vasicinone and may be responsible for the action of Adhatoda. Vasicinone is the autooxidation product of vasicine.Cambridge et al. stated that in vitro tests showed relaxation of guinea pig trachea rings by vasicinone and quinazol4one at about 1/2000 the activity of adrenaline.Vasicinone was 1/700 and quinazol4one was 1/3800 as active as adrenaline against histamineinduced contraction. In in vivo studies of anesthetized guinea pigs, vasicine produced bronchoconstriction at high doses. Vasicine and vasicinone were found to have a weak antihistaminic effect which was of short duration. Vasicinone had less antihistaminic activity than vasicine and the effect decreased at higher doses.(http://www.whereincity.com/)

 

 

SALES SPECIFICATION

APPEARANCE

white to yellow powder

ASSAY

98.0% min

MELTING POINT

209 - 211 C

 

PRICE INFORMATION

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