TRIPTOLIDE

Triptolid; (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy- 8b-methyl-6a- (1-methylethyl)trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one;

 TRIPTOLIDE

 

PRODUCT IDENTIFICATION

CAS RN

38748-32-2

EINECS RN

 

FORMULA

C20H24O6

MOLE WEIGHT

360.40

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white powder

MELTING POINT

235 - 237 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

(Soluble in DMSO)

pH

 

VAPOR DENSITY

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions

INCOMPATIBLE MATERIALS

Strong acids, Strong bases

DECOMPOSITION PRODUCTS

Carbon oxides.

POLYMERIZATION Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

SAFETY

HAZARD NOTES

 

EYE

May cause eye irritation.

SKIN

May be harmful if absorbed through skin. May cause skin irritation.

INGESTION

May be harmful if swallowed.

INHALATION

May be harmful if inhaled. May cause respiratory tract irritation.

CHRONIC

 

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 
HAZARD CLASS

 

PACKING GROUP

 

HAZARD CODE

 

RISK STATEMENTS

 

SAFETY STATEMENTS

22-24/25

 

EXTERNAL LINKS & GENERAL INFORMATION
Celastrol has been effectively used in the treatment of autoimmune diseases, asthma, chronic inflammation, and neurodegenerative disease. Under in vitro conditions, Celastrol was found to inhibit cancer cell proliferation and induce leukemic cell death; however, the molecular mechanism involved still remains unclear. (http://cancerres.aacrjournals.org/)

Tripterine (celastrol) is a pentacyclic triterpenoid antioxidant compound isolated from the Chinese Tripterygium wilfordii Hook. It has an activity of immunosuppressive and anti-inflammatory. Triterpenes antioxidants are not common, but tripterine's antioxidant potency is equivalent to about 15 times that of alpha-tocopherol.

Triptolide (PG490, 97% pure) is a diterpenoid triepoxide with potent anti-inflammatory and immunosuppressive effects in transformed human bronchial epithelial cells and T cells (Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC-H, and Kao PN. J Biol Chem 274: 13443-13450, 1999). Triptolide, with an IC50 of ~20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-α, or IL-1β. Nuclear runoff and luciferase reporter gene assays demonstrate that triptolide inhibits IL-8 transcription. Triptolide also inhibits the transcriptional activation, but not the DNA binding, of nuclear factor-κ. A cDNA array and clustering algorithm analysis reveals that triptolide inhibits expression of the PMA-induced genes tumor necrosis factor-α, IL-8, macrophage inflammatory protein-2α, intercellular adhesion molecule-1, integrin β6, vascular endothelial growth factor, granulocyte-macrophage colony-stimulating factor, GATA-3, fra-1, and NF45. Triptolide also inhibits constitutively expressed cell cycle regulators and survival genes cyclins D1, B1, and A1, cdc-25, bcl-x, and c-jun. Thus anti-inflammatory, antiproliferative, and proapoptotic properties of triptolide are associated with inhibition of nuclear factor-κ signaling and inhibition of genes known to regulate cell cycle progression and survival. http://ajplung.physiology.org/cgi/content/full/279/5/L958 (  http://cancerres.aacrjournals.org/)

Triptolide, a diterpenoid isolated from the Chinese herb Tripterygium wilfordii Hook F, has been demonstrated to be effective in the treatment of a variety of autoimmune diseases. T helper type 17 (Th17) cells represent a novel subset of CD4(+) T cells involved in the immunopathogenesis of autoimmune diseases. Currently, the effects of triptolide on the differentiation of Th17 cells remain unclear. Here, we found that triptolide significantly inhibited the generation of Th17 cells from murine splenocytes and purified CD4(+) T cells in a dose-dependent manner. The suppressive effects of triptolide were persistent even after it had been removed from cell cultures. (http://www.ncbi.nlm.nih.gov/)

Pharmacological actions:
  • Alkylating antineoplastic
  • Contraceptive
  • Antispermatogenic
  • Immunosuppressive

Contraceptive agents

Product

CAS RN.

5-Thio-D-glucose 20408-97-3
Algestone acetophenide 24356-94-3
Algestone 595-77-7
Anordiol 1045-30-3
Anordrin 56470-64-5
Bisecurin I 8056-92-6
Centchroman 31477-60-8
Chlormadinone acetate 302-22-7
Chlormadinone Acetate 302-22-7
Cloprostenol 40665-92-7
Cyproterone acetate 427-51-0
Desogestrel 54024-22-5
Diallyl disulfide 2179-57-9
Diallyl trisulfide 2050-87-5
Dienogest 65928-58-7
Dimethisterone 79-64-1

Estradiol benzoate

50-50-0

Estradiol cypionate 313-06-4
Estradiol valerate 979-32-8
Estropipate 7280-37-7
Ethinyl estradiol 57-63-6
Ethynodiol diacetate 297-76-7
Etonogestrel 54048-10-1
Fluprostenol 40666-16-8
Gestodene 60282-87-3
Gestrinone 16320-04-0
Gossypol acetic acid 12542-36-8
Gossypol 303-45-7
Levonorgestrel 797-63-7

L-Norgestrel

17489-40-6

Lonidamine 50264-69-2
Lynestrenol 52-76-6
Medroxyprogesterone acetate 71-58-9
Medroxyprogesterone 520-85-4
Megestrol 3562-63-8
Mestranol 72-33-3
Mifepristone 84371-65-3
Molinate 2212-67-1
Neem oil 8002-65-1
Nestorone 7759-35-5
Nonoxynol 15 26027-38-3
Norelgestromin 53016-31-2
Norethindrone enanthate 3836-23-5
Norethindrone acetate 51-98-9
Norethindrone 68-22-4
Norethynodrel 68-23-5
Norgestimate 35189-28-7
Norgestrel 6533-00-2
Norgestrienone 848-21-5
Octoxynol 9 9002-93-1
p-Coumaric acid 7400-08-0
Plumbagin 481-42-5
Polyethylene glycol octylphenyl ether 9036-19-5

Progesterone

57-83-0

Sodium polystyrene sulfonate 37349-16-9
Sulprostone 60325-46-4
Trestolone 3764-87-2
Triptolide 38748-32-2
Triptorelin 57773-63-4

 

SALES SPECIFICATION

APPEARANCE

white to yellow crystalline powder

ASSAY

98.0% min

WATER

2.0% min

 

PRICE INFORMATION

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