SALICIN

SALICIN

2-(Hydroxymethyl)phenyl beta-D-glucopyranoside; o-Hydroxybenzyl alcohol o-glucoside; Salicine; Salicoside; Salicyl alcohol glucoside; Saligenin beta-D-glucopyranoside; Saligenin-beta-D-glucopyranoside; o-(Hydroxymethyl)phenyl beta-D-glucopyranoside;

SALICIN

PRODUCT IDENTIFICATION
CAS RN	138-52-3
EINECS RN	205-331-6
FORMULA	C₁₃H₁₈O₇
MOLE WEIGHT	286.28
CHEMICAL FAMILY	Monosaccharide
CATEGORIES	Extractives and their physically modified derivatives

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white crystals with characteristic odor
MELTING POINT	197 - 200 C
BOILING POINT
DENSITY
SOLUBILITY IN WATER	Soluble (Soluble in alkalies, pyridine)
pH
VAPOR DENSITY
REFRACTIVE INDEX
FLASH POINT

STABILITY AND REACTIVITY
STABILITY	Stable under normal conditions.
INCOMPATIBLE MATERIALS	Strong oxidizing agents
DECOMPOSITION PRODUCTS	Carbon oxides
POLYMERIZATION
TOXICOLOGICAL

SAFETY
HAZARD NOTES	May cause an allergic skin reaction.
EYE	Causes eye irritation.
SKIN	Harmful if absorbed through skin. Causes skin irritation.
INGESTION	Harmful if swallowed.
INHALATION	Harmful if inhaled. Causes respiratory tract irritation.
TARGET ORGANS
CHRONIC

TRANSPORT & REGULATORY INFORMATION
UN NO.
HAZARD CLASS
PACKING GROUP
HAZARD SYMBOL	XI
RISK PHRASES	43
SAFETY PHRASES	36/37

EXTERNAL LINKS & GENERAL INFORMATION

Wikipedia Linking: http://en.wikipedia.org/wiki/Salicin

Salicinum, Salicin, C₁₃H₁₈O₇,- is a neutral principle obtained from several species of Salix (willow) and Populus (poplar), also found in Gaultheria procumbens (wintergreen) and in Betula lenta (sweet birch), the volatile oils of which consist almost entirely of methyl salicylate. It occurs in white, silky, crystalline needles; soluble in 28 of water and in 30 of alcohol. Acidum Salicylicum, Salicylic Acid, HC₇H₅O₃,- is an organic acid, existing in various plants, but most largely prepared synthetically from carbolic acid. Occurs in fine, prismatic needles or a crystalline powder; soluble in about 450 of water and in 2 1/2 of alcohol, but readily soluble in water containing 8 per cent. of borax or 10 of sodium phosphate. Salicylic Acid is a derivative of Salicin, probably by solid oxidation; but may also be considered as a substitution-derivative of Benzene, formed by replacing 2 atoms of its hydrogen, the one by hydroxyl, and the other by carboxyl. It is obtained, therefore, either synthetically by combining the elements of Carbolic Acid with those of Carbonic Acid, and subsequent purification,-or from natural Salicylates as the oils of wintergreen and sweet birch,- or from Salicin, by heating with caustic potash and treating the mass with hydrochloric acid. The acid prepared from natural sources is purer and more efficient than that prepared artificially, and will often be tolerated by a patient who cannot bear the latter. (http://www.henriettesherbal.com/)

Herbalists have used extract of the bark of the willow (Salix spp.) to treat a variety of complaints. The name salicin was given to the basic compound with a molecule incorporating 2 rings. One of these rings is equivalent to a glucose molecule, so this called a glycoside. A similar substance is produced by other plants, such as the Meadowsweet flower. By removing the glucose unit from salicin, a molecule with a single ring structure was obtained: salicylic acid (ortho hydroxy benzoic acid). This substance was not very effective as a drug. Interestingly, the name aspirin - registered in 1899 - results from a for acetyl + spirin, meaning a substance obtained from Spiraea, which is the name which used to be given to the plant Meadowsweet. (http://www.biotopics.co.uk/)

The bark of white willow contains salicin, which is a substance similar to aspirin (acetylsalicylic acid). Salicin may be the chemical involved in the pain-reliving and anti-inflammatory effects of the white willow herb. In fact, in the 1800s, salicin was used to develop aspirin. White willow bark extract does appear to have some analgesic properties. (http://www.raysahelian.com/)

Pharmacological actions:

Non-Narcotic Analgesic
Anti-Inflammatory Agent
Non-Steroidal Anti-Inflammatory Agent
Cyclooxygenase Inhibitor
Peripheral Nervous System Agent

SALES SPECIFICATION
APPEARANCE	white powders with characteristic odor
SALICIN	98.0%
MELTING POINT	197 - 200 C
HEAVY METALS	10ppm max
ARSENIC	1ppm max
LOSS ON DRYING	1.0% max
ASH	0.5% max
MICROBIOLOGICAL TESTS	Total plate count: 1000CFU/g mac Yeast and mold: 100CFU/g Salmonella: negative E.Coli: negative Staphylococcus: negative P.Aeruginosa: negative

PACKING

PRICE