ZIDOVUDINE (3'-AZIDO-3'-DEOXYTHYMIDINE)

ZIDOVUDINE
PRODUCT IDENTIFICATION
CAS NO.	30516-87-1 (Base) 106060-86-0 (sodium salt)
EINECS NO.
FORMULA	C₁₀H₁₃N₅O₄
MOL WT.	267.24
H.S. CODE
TOXICITY
SMILES
SYNONYMS	3-Azido-3-deoxythymidine; AZT; ZDV; ZVD;
3'-deoxy-3'-azidothymidine; azidodeoxythymidine; Azidothymidine; 3'-Azidothymidine; 3'-Azido-3'-deoxythymidine;
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	White to off-white Crystals
MELTING POINT	110 - 115 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health: 1 Flammability: 1 Reactivity: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions
GENERAL DESCRIPTION & APPLICATIONS
Zidovudine is a thymidine analogue in which the 3'-hydroxy (-OH) group is replaced by an azido (-N3) group. It is used in the management of human immunodeficiency virus. It is an antiretroviral agent that inhibits replication of some retroviruses. It is converted into the active metabolite zidovudine 5'-triphosphate which inhibits the activity of the HIV (human immunodeficiency virus) reverse transcriptase within cells. The viral DNA growth is terminated due to the lack of 3'-OH group which prevents the formation of the essential for DNA chain elongation (5' to 3' phosphodiester). Zalcitabine (2',3'-dideoxycytidine), a 2'-deoxycytidine analogue which does not have -OH group both at 2' and at 3' position, is an antiretroviral agent used in combination with zidovudine. Zalcitabine is converted into the active metabolite dideoxycytidine 5'-triphosphate that inhibits the action of reverse transcriptase. 3'-Azido-3'-deoxythymidine and 2',3'-dideoxycytidine are used in the study for antiviral and anticancer researches. Protease inhibitors are the second class of antiretroviral drugs for the treatment of HIV. Aantiretroviral agents Non-nucleoside reverse transcriptase inhibitors Delavirdine [CAS #: 136817-59-9] Delavirdine mesylate [CAS #: 147221-93-0] Efavirenz [CAS #: 154598-52-4] Nevirapine [CAS #: 129618-40-2] Nucleoside/Nucleotide reverse transcriptase inhibitors Abacavir [CAS #: 136470-78-5] Abacavir succinate [CAS #: 168146-84-7] Abacavir sulfate [CAS #: 188062-50-2] Adefovir [CAS #: 106941-25-7] Adefovir dipivoxil [CAS #: 142340-99-6] Combivir (Lamivudine/Zidovudine mixture) [CAS #: 165456-81-5] Didanosine [CAS #: 69655-05-6] Emtricitabine [CAS #: 143491-57-0] Lamivudine [CAS #: 134678-17-4] Lamivudine sulfoxide [CAS #: 160552-55-6] Pradefovir mesylate [CAS #: 625095-61-6] Stampidine [CAS #: 217178-62-6] Stavudine [CAS #: 3056-17-5] Tenofovir [CAS #: 147127-20-6] Tenofovir disoproxil [CAS #: 201341-05-1] Tenofovir Disoproxil Fumarate [CAS #: 202138-50-9] Trizivir (Abacavir sulfate/Lamivudine/Zidovudine mixture) [CAS #: 364057-50-1] Zalcitabine [CAS #: 7481-89-2] Zidovudine [CAS #: 30516-87-1] Zidovudine sodium salt [CAS #: 106060-86-0] Protease inhibitors Amprenavir [CAS #: 161814-49-9] Atazanavir [CAS #: 198904-31-3] Atazanavir sulfate [CAS #: 229975-97-7] Fosamprenavir [CAS #: 226700-79-4] Fosamprenavir calcium [CAS #: 226700-81-8] Fosamprenavir sodium [CAS #: 226700-80-7] Indinavir [CAS #: 150378-17-9] Indinavir hydrate [CAS #: 180683-37-8] Indinavir Sulfate [CAS #: 157810-81-6] Kaletra (Lopinavir/Ritonavir mixture) [CAS #: 369372-47-4] Lopinavir [CAS #: 192725-17-0 Nelfinavir [CAS #: 159989-64-7] Nelfinavir mesylate [CAS #: 159989-65-8] Ritonavir [CAS #: 155213-67-5] Saquinavir [CAS #: 127779-20-8] Saquinavir mesylate [CAS #: 149845-06-7] Tipranavir [CAS #: 174484-41-4] Tipranavir disodium [CAS #: 191150-83-1]
SALES SPECIFICATION
APPEARANCE	White to off-white Crystals
IDENTIFICATION	passes test A,B
ASSAY	99.0% min
OPTICAL ROTATION	+46° ~ +48° (C=0.5 in water)
WATER	0.5% max
HEAVY METALS	20ppm max
LOSS ON DRYING	0.5% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases: 40, Safety Phrases:` 36/37/39-45 OTHER INFORMATION