FELODIPINE

PRODUCT IDENTIFICATION

CAS NO. 72509-76-3, 86189-69-7

FELODIPINE

EINECS NO.  
FORMULA C18H19Cl2NO4
MOL WT. 384.26

H.S. CODE

 

TOXICITY

 
SYNONYMS Plendil;
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester; (±)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5- pyridinedicarboxylate;

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 142 - 145 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

stable under ordinary conditions.

APPLICATIONS

Calcium ions are needed for electrical activity for the contraction of cardiac and smooth muscle and conduction of nerve cell. Calcium channel blocker is a drug which inhibits the entry of excess calcium into cells and/or prevents form the mobilization of calcium from intracellular stores, resulting in relaxation of blood vessel walls and cardiac muscle for blood to flow more freely, lowering blood pressure thereby reducing oxygen demand in the heart and relieving anginal pain. It is used in the treatment of angina, cardiac arrhythmias, and hypertension.

Some major calcium channel blockers upon chemical structure are:

  • Dihydropyridine calcium channel blockers ; Amlodipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nisoldipine, Nitrendipine, Nimodipine.
  • Phenylalkylamine calcium channel blockers ; Gallopamil, Verapamil
  • Benzothiazepine calcium channel blockers; Diltiazem
  • Diarylaminopropylamine ethers; Bepridil, Mibefradil

Felodipine is a medication belongs to dihydropyridine calcium channel blockers. Chemical designation is (±)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5- pyridinedicarboxylate. It is a yellowish crystalline powder; melting point 142 - 145 C; insoluble in water; soluble in chloroform, alcohol.

SALES SPECIFICATION ( USP25)

APPEARANCE

yellowish crystalline powder

ASSAY

98.0 - 102.0%

IDENTIFICATION

pass

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

20ppm max

MELTING POINT 142 - 145 C
TOTAL IMPURITY

1.5% max (Individual impurity: 1.0% max)

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22/36/37/38, Safety Phrases: 24/25
PRICE INFORMATION
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