CIPROFLOXACIN

GENERAL DESCRIPTION

Ciprofloxacin, chemically 1,4-dihydro-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-Quinolinecarboxylic acid, is a quinolone antibiotic drug used mainly to treat the respiratory infections (pneumoniae, pseudomonas, influenzae), urinary tract infections, the gastrointestinal surgery,  typhoid fever, gonorrhoeab (enterotoxigenic strains of Escherichia coli), and septicaemia. Ciprofloxacin act by inhibiting the bacterial enzymes DNA gyrase. Other quinolones include cinoxacin; levofloxacin; nalidixic acid; norfloxacin; ofloxacin.

CLINICAL APPLICATIONS;
-Uncomplicated urinary tract infections
-Complicated urinary tract infections
-Pyelonephritis
-sexually transmitted diseases
-prostatitis
-skin and tissue infections
-Urethral and cervical gonococcal infections

STRUCTURE

CAS NO.

 CIPROFLOXACIN

85721-33-1

ACTIVITY

FLUOROQUINOLONES

MOL WT.

C17H18FN3O3
331.35

SYNONYMS 0R BRAND NAME
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Ciloxin; Baycip; Ciloxan; Ciprinol; Flociprin; BRAND NAME(S):
Cipro (Miles); Ciloxan (Alcon); Ciflox (Bayer); Ciprobay (Bayer); Ciproxin (Bayer)

SPECIFICATION & DESCRIPTION

CIPROFLOXACIN BASE

APPEARANCE

white to pale yellowcrystalline powder
IDENTIFICATION

Conforms to USP23

ASSAY

98.5%--101.5%
CLARITY OF SOLUTION clear to slightly opalescent
FLUOROQUINOLONIC ACID 0.2% max
LOSS ON DRYING 1.0% max
SULPHATED ASH 0.1% max
HEAVY METALS 0.002% max
RESIDUE ON IGNITION 0.1% max
CIPROFLOXACIN HYDROCHLORIDE

APPEARANCE

white to pale yellow crystalline powder

IDENTIFICATION

Conforms to USP23

ASSAY

98.5%--101.5%
CLARITY OF SOLUTION clear to slightly opalescent
FLUOROQUINOLONIC ACID 0.2% max

WATER

4.5% - 7.0%

pH

3.0 - 4.5

SULPHATED ASH 0.1% max
HEAVY METALS 0.002% max
RESIDUE ON IGNITION 0.1% max
PRICE INFORMATION
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