CEFTRIAXONE DISODIUM

PRODUCT IDENTIFICATION
CAS NO. 73384-59-5 (Base)
74578-69-1 (Disodium)

CEFTRIAXONE DISODIUM 

EINECS NO. 277-405-6, 277-930-0
FORMULA C18H16N8O7S3Na2·3.5H2O
MOL WT. 661.59

H.S. CODE

 2941.90.5000

TOXICITY

  
SYNONYMS RoceFin; Rocephin;
Disodium(-)-(6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido] -3- (2,5-dihydro- 2-methyl-6-oxide-5-oxo-1,2,4-triazin- 3-ylthiomethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct- 2-ene-2-carboxylate hemiheptahydrate; (6R,7R)-7-[2- (2-Amino-4-thiazolyl)glyoxylamido]- 8-oxo-3-[[(1,2,5,6- tetrahydro-2-methyl- 5,6-dioxo- as-triazin-3-yl)thio]methyl]-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2- carboxyalic acid, 7²-(Z)-(O-methyloxime), disodium salt, hydrate;

SMILES

Cn1c(nc(=O)c(n1)[O-])SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/ C(=N\O C) /c 4csc(n4)N)SC2)C(=O)[O-].[Na+].[Na+]

CLASSIFICATION

Antiboitics, Cephalosporins

EXTRA NOTES

A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. [MeSH]
Other RN: 104376-79-6 (disodium hemiheptahydrate), 74578-69-1 (dihydrochloride hemiheptahydrate)

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White to slightly yellowish crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Readily soluble (sparingly soluble in methanol, ethanol)
pH 6 - 8 (1% sol.)
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Ceftriaxone

Wikipedia Linking - Ceftriaxone

Google Scholar Search - Ceftriaxone

U.S. National Library of Medicine - Ceftriaxone

PubChem Compound Summary - Ceftriaxone

Drug Bank -  Ceftriaxone

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Ceftriaxone

ChEBI (http://www.ebi.ac.uk/chebi/) -  Ceftriaxone

NCBI (http://www.ncbi.nlm.nih.gov/) -  Ceftriaxone

EPA - Substance Registry Services - Ceftriaxone

Local:
Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium  and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. Third-generation cephalosporins are more active against gram-negative organisms but less active against gram-positive organisms than second-generation agents; examples are cefoperazone, cefotaxime, ceftriaxone, ceftazidime, ceftizoxime, and moxalactam.

SALES SPECIFICATION

APPEARANCE

 White to slightly yellowish crystalline powder

ASSAY

 795ug/mg min (Ceftriaxone),
96.0~102.0% (Ceftriaxone Sodium ;as anhydrous basis)
MOISTURE 8.0 ~11.0%

pH

 6 - 8 (1% aq sol.)

HEAVY METALS

20ppm max

OPTICAL ROTATION

 -153° ~ -170°
TRANSPORTATION
PACKING

5kgs - 20kgs

HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Skin irritation. Eye irritation. Respiratory sensitization. Skin sensitization. Specific target organ toxicity - single exposure. Hazard statements: Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

GHS

 

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H315-H317-H319-H334-H335

P STATEMENTS

P261-P280-P305 + P351 + P338-P342 + P311

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

36/37/38-42/43

SAFETY PHRASES

26-36

PRICE INFORMATION