PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

(±)-1-(Carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy) ethyl] aminol-2-propanol; 1-(9H-Carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propanol;

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

Stable under ordinary conditions. Hygroscopic.

APPLICATIONS

Carvedilol is a combined medicine of Alpha (alpha-adrenoceptor blockers) and Beta-blockers (beta-adrenoceptor blockers) capable of blocking both alpha and beta receptors to treat high blood pressure and to prevent cardiac arrhythmias and angina. Carvedilol is a white to off-white crystalline powder; soluble in dimethylsulfoxide, methylene chloride, DMF, methanol; sparingly soluble in ethanol, isopropanol; slightly soluble in ethyl ether; insoluble in water. Chemically it is described as (±)-1-(Carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy) ethyl] aminol-2-propanol. Examples of alpha-beta combined brokers are carvedilol and labetalol, alpha-Brokers; alfuzosin, doxazosin, indoramin, phenoxybenzamine, phentolamine, prazosin, tamsulosin, terazosin, thymoxamine and beta-blockers examples include atenolol, metoprolol, oxprenolol, propranolol (most of the generic names for beta blockers end with 'olol').

BIBLIOGRAPHY

USP23 / BP93

APPEARANCE

IDENTIFICATION

complies with Test A (IR spectrum)

ASSAY

0.1% max

0.2% max

HEAVY METALS

20ppm max

1.0% max

We respect the intellectual property of Yamanouchi's U.S.Patent Nos. 4,703,063, 4761,500, 4772,475 and 4,868,216, 4,987,152. We are not offering tamsulosin in the United States.