PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
REFRACTIVE INDEX
stable under ordinary conditions.
APPLICATIONS
APPEARANCE
ASSAY
99.0% min
pass
ASH
0.1% max
HEAVY METALS
20ppm max
0.5% max
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| ANTIPYRINE | |||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 60-80-0 |
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| EINECS NO. | 200-486-6 | ||
| FORMULA | C11H12N2O | ||
| MOL WT. | 188.23 | ||
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H.S. CODE |
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TOXICITY |
Oral rat LD50: 1705 mg/kg | ||
| SYNONYMS | Phenazone; 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one; | ||
| 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; beta-Antipyrine; Dimethyloxychinizin; Dimethyloxyquinazine; Oxydimethylquinazine; Oxydimethylquinizine; 3-Antipyrine; 1,5-Dimethyl-2-phenyl-3-pyrazolone; 2,3-Dimethyl-1-phenyl-5-pyrazolone; 1-Phenyl-2,3-dimethylpyrazole-5-one; | |||
| SMILES |
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| CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white crystalline powder | ||
| MELTING POINT | 110 - 113 C | ||
| BOILING POINT | 319 C | ||
| SPECIFIC GRAVITY | 1.19 | ||
| SOLUBILITY IN WATER | soluble | ||
| pH | |||
| VAPOR DENSITY |
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| AUTOIGNITION |
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| NFPA RATINGS | Health: 1; Flammability: 0; Reactivity: 0 | ||
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REFRACTIVE INDEX |
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| FLASH POINT | |||
| STABILITY |
stable under ordinary conditions. |
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APPLICATIONS |
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| Pyrazolone is a five-membered lactam ring compound containing two nitrogens and
ketone in the same molecule. Lactam structure is an active nucleuses in
pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical
ingredient, especially in the class of nonsteroidal antiinflammatory agents used
in the treatment of arthritis and other musculoskeletal and joint disorders. The term of pyrazolone sometimes
refers to nonsteroidal anti-inflammatory agents. Pyrazolone
class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone,
oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in
otic solutions in combination with other analgesic such as benzocaine, and
phenylephrine. Antipyrine has been used as an antipyretic, but replaced due to
the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. |
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| SALES SPECIFICATION (BP98 / USP23) | |||
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APPEARANCE |
white crystalline powder | ||
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ASSAY |
99.0% min |
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| IDENTIFICATION |
pass |
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ASH |
0.1% max |
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HEAVY METALS |
20ppm max |
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| MELTING POINT | 110 - 113 C | ||
| LOSS ON DRYING |
0.5% max |
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| TRANSPORTATION | |||
| PACKING |
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| HAZARD CLASS | not regulated | ||
| UN NO. | |||
| OTHER INFORMATION | |||
| Hazard Symbols: XN, Risk Phrases: 22/36/37/38, Safety Phrases: 24/25 | |||
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