ALFACALCIDOL

PRODUCT IDENTIFICATION
CAS NO. 41294-56-8

ALFACALCIDOL

EINECS NO. 255-297-1
FORMULA C27H44O2
MOL WT. 400.64

H.S. CODE

  

TOXICITY

 
SYNONYMS 1-Hydroxycholecalciferol; 1alpha-Hydroxycholecalciferol;
(5Z,7E)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol; 1-Hydroxyvitamin D3; 1alpha- Hydroxy- vitamin D3; Alfacalcidolum; Alfarol; Alpha D3; Alphacalcidol; 9,10-Secocholesta-, 7,10(19)- triene -1alpha,3beta-dioll; (1R,3S)-5-[2-[(1R,3aR,7aS)-7a-Methyl-1- [(2R)-6-methylheptan-2- yl]-2,3,3a, 5,6,7 -hexahydro-1H-inden-4-ylidene]ethylidene] -4-methylidene-cyclohexane-1,3-diol; 1-alpha- oxycholecalciferol 1alpha-OHD3;

CLASSIFICATION

 VITAMINS / BONE DENSITY REGULATORS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 136 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Calcitriol, 1,25-dihydroxycholecalciferol, is the physiologically active form of vitamin D which contributes to the intestinal absorption of Ca2+ and Ca2+ resorption by bone. Calcitriol is a steroid hormone found in the body. Calcitriol is used as a medication in the treatment of hypocalcaemia, hypophosphatemia, rickets, and osteoporosis. Calcifediol (25-hydroxycholecalciferol) is a prehormone which is produced by the metabolism of cholecalciferol. Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcifediol is converted by the kidneys into calcitriol and calcitriol is converted into alfacalcidol in the liver.

Bone Density Regulators

CAS RN
Alendronate sodium 121268-17-5
Alendronic acid 66376-36-1
Alfacalcidol 41294-56-8
Calcifediol 63283-36-3
Calcitonin 47931-85-1
Calcitriol 32222-06-3

Cholecalciferol

 67-97-0
Clodronic acid 10596-23-3
Dihydrotachysterol 67-96-9
Disodium cycloheptylaminomethylenediphosphonate 138330-18-4
Ergocalciferol 50-14-6
Etidronate Disodium 7414-83-7
Etidronic acid 2809-21-4
Gallium nitrate 135886-70-3
Hydroxycholecalciferols

 
Ibandronate sodium hydrate 138926-19-9

Ibandronic acid

 114084-78-5

Olpadronic acid

 63132-39-8
Oxidronic acid 15468-10-7
Pamidronate disodium 109552-15-0
Pamidronic acid disodium salt 57248-88-1
Pamidronic acid 40391-99-9
Potassium phosphate dibasic 7758-11-4
Procalcitonin 56645-65-9

Raloxifene

 84449-90-1
Risedronate sodium 115436-72-1

Risedronic acid

 105462-24-6
Secalciferol 55721-11-4

Tamoxifen

 10540-29-1

Teriparatide

 52232-67-4

Tiludronic acid

 89987-06-4
Toremifene citrate 89778-27-8

Toremifene

 89778-26-7

Vitamin D

 1406-16-2
Vitamin D2 sulfate 1784-46-9

Zoledronic acid

 118072-93-8
24,25-Dihydroxyvitamin D 3 40013-87-4

25-Hydroxyvitamin D 2

 21343-40-8
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder
IDENTIFICATION Conform to Test A (IR absorption), B (HPLC)

ASSAY

 97.0 - 103.0%
RELATED SUBSTANCES 1.0% max
INDIVIDUAL SUBSTANCES

0.5% max
SOLVENT RESIDUES Dichloromethane: 0.06% max
Methanol: 0.3% max
Other residual solvent: 0.1% max
TRANSPORTATION
PACKING
 
HAZARD CLASS 6.1 (Packing Group: I)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T+, Risk Phrases: 26/27/28-63, Safety Phrases: 36/37/39-45
PRICE INFORMATION

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