CHOLESTYRAMINE

Synonym: Cholestyramine resin; Cholestyramine; Cholestyramine chloride; Cholybar; Colestiramina; Colestyramin; Colestyraminum; Duolite; Locholest; Polystyrene benzyltrimethylaminonium chloride; Prevalite; Quantalan; Questran;

 

 

PRODUCT IDENTIFICATION

CAS RN

11041-12-6 Other RN: 9007-26-5, 58391-37-0

EINECS RN

234-270-8

FORMULA

 

MOLE WEIGHT

 

H.S CODE

3914.00.6000

SMILES

 

CLASSIFICATION

Anion exchange resin, Ion Exchange Resin, Anticholesteremic agent, Antihyperlipidemic, Antilipemic agent, Antimetabolite, Hypolipidemic, Bile acid sequestrant

EXTRA NOTES

Lipid Regulating Agent
Quartenary ammonium functional groups attached to cross-linked polystyrene
A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium as Cl(-) anion. It exchanges chloride ions with bile salts, thus decreasing their concentration and that of cholesterol. It is used as a hypocholesteremic in diarrhea and biliary obstruction, and as an antipruritic.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white fine powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Practically insoluble

SOLVENT SOLUBILITY

Practically insoluble in ethanol

VAPOR DENSITY

 

OH RATE CONSTANT  
pH

4.0 - 6.0

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

 
DECOMPOSITION PRODUCTS

not known.

POLYMERIZATION  

NFPA RATINGS

Health Hazard: 1, Fire: 0, Reactivity Hazard: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Cholestyramine

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Cholestyramine

PubChem Compound Summary - Cholestyramine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Cholestyramine

http://www.ebi.ac.uk/chebi/ - Cholestyramine

http://www.ncbi.nlm.nih.gov/ - Cholestyramine

Human Metabolome Database - Cholestyramine

http://dailymed.nlm.nih.gov/
Cholestyramine for Oral Suspension USP, the chloride salt of a basic anion exchange resin, a cholesterol lowering agent, is intended for oral administration. Cholestyramine resin is quite hydrophilic, but insoluble in water. The cholestyramine resin in Cholestyramine is not absorbed from the digestive tract. Four grams of anhydrous cholestyramine resin is contained in 9 grams of Cholestyramine for Oral Suspension USP. Four grams of anhydrous cholestyramine resin is contained in 5 grams of Cholestyramine for Oral Suspension USP, Light. It is represented by the following structural formula: Cholestyramine for Oral Suspension USP contains the following inactive ingredients: acacia, citric acid, D&C Yellow No. 10, FD&C Yellow No. 6, flavor (natural and artificial Orange), polysorbate 80, propylene glycol alginate and sucrose. Cholestyramine for Oral Suspension USP, Light contains the following inactive ingredients: aspartame, citric acid, colloidal silicon dioxide, D&C Yellow No. 10, FD&C Red No. 40, flavor (natural and artificial Orange), maltodextrin, propylene glycol alginate and xanthan gum.

http://www.ncbi.nlm.nih.gov/
Comparison of the In Vitro Activities of Teicoplanin and Vancomycin against Clostridium difficile and Their Interactions with Cholestyramine

 

 

SALES SPECIFICATION

APPEARANCE

white to off-white fine powder

IDENTIFICATION

passes Test (IR)

pH

4.0 - 6.0

LOSS ON DRYING

12.0% max
AMMONIUM CHLORIDE
13.0-17.0% (on drying basis)

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

20ppm max

DIALYZABLE QUATERNARY AMINES

0.05% max as Benzyltrimethyleammonium Chloride

EXCHANGE CAPACITY
Exchange sodium taurocholate: 2.0-2.2g (on drying basis)
MIRCOBIAL TEST

 

TOTAL PLATE COUNT
1000/g max
YEAST AND MOLD
100/g max
E.COLI
Negative
ACTIVE ACARUS
Negative

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD SYMBOL

 

PACKING GROUP

 

 

SAFETY INFORMATION

HAZARD OVERVIEW

Not known

EC DIRECTIVES

 

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

22  Do not breathe dust
24/25  
Avoid contact with skin and eyes

 

PACKING

 

 

PRICE INFORMATION