DONEPEZIL HYDROCHLORIDE

1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride; 2,3-Dihydro-5,6-dimethoxy-2-((1- (phenylmethyl)-4-piperidinyl) methyl)-1H-inden-1-one; Aricept;

DONEPEZIL

PRODUCT IDENTIFICATION

CAS RN

120014-06-4 (parent); 120011-70-3; 142057-77-0 (HCl)

EINECS RN

 

FORMULA

C24H29NO3· HCl

MOLE WEIGHT

415.95

CHEMICAL FAMILY

Piperidine derivative

CATEGORIES

Alzheimer's disease treatment

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

yellow crystalline powder

MELTING POINT

211 - 212 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Soluble (Soluble in chloroform, acetic acid; sparingly soluble in methanol; slightly soluble in ethanol and in acetonitrile; practically insoluble in ethyl acetate and in n-hexane)

pH

 

VAPOR DENSITY

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBILITIES

Strong bases

DECOMPOSITION PRODUCTS

Carbon oxides, Nitrogen oxides, Chloride gas

POLYMERIZATION Will not occur

TOXICOLOGICAL

Oral Rat LD50: 32.6 mg/kg

 

SAFETY

HAZARD NOTES

Poison

EYE

May cause eye irritation.

SKIN

May be harmful if absorbed through skin. May cause skin irritation.

INGESTION

May cause irritation. This material is well absorbed from the gastrointestinal tract.

INHALATION

May cause irritation. May cause respiratory tract irritation.

TARGET ORGANS

 

CHRONIC

Hypersensitization

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811
HAZARD CLASS

6.1

PACKING GROUP

II

HAZARD SYMBOL

T

RISK PHRASES

25

SAFETY PHRASES

45

 

EXTERNAL LINKS & GENERAL INFORMATION

Wikipedia Linking: http://en.wikipedia.org/wiki/Donepezil

People who have depression along with mild cognitive impairment and take the popular Alzheimer’s drug donepezil may help delay the progression to full-blown Alzheimer’s disease, according to new research. The research also found that people who are depressed with existing mild memory problems or mild cognitive impairment are more likely to develop Alzheimer’s disease than those without depression. (http://psychcentral.com/)

Donepezil is an oral medication used to treat Alzheimer's disease. It belongs to a class of drugs called cholinesterase inhibitors that also includes tacrine (Cognex). Scientists believe that Alzheimer's disease may result from a deficiency in chemicals (neurotransmitters) used by nerves in the brain to communicate with one another. Donepezil inhibits acetylcholinesterase, an enzyme responsible for the destruction of one neurotransmitter, acetylcholine. This leads to increased concentrations of acetylcholine in the brain, and the increased concentrations are believed to be responsible for the improvement seen during treatment with donepezil. Donepezil improves the symptoms but does not slow down the progression of Alzheimer's disease. Donepezil was approved by the FDA in 1996. (http://www.medicinenet.com/)

Alzheimer's disease is a progressive degenerative disease of the brain and is a form of dementia. Characterized by a slow, progressive decline in mental and social function, Alzheimer's disease impairs memory, thinking, judgment, and the ability to learn. Alzheimer's disease can also affect personality and the ability to make decisions. The risk of developing Alzheimer's disease increases with age and is greater for women than for men. (http://www.mercksource.com/)

Pharmacological Actions:

  • Central Nervous System Agent
  • Cholinergic Agent
  • Cholinesterase Inhibitor
  • Neurotransmitter Agent
  • Nootropic Agent
Drugs used for the treatment of Alzheimer's disease

Product

CAS RN.

Galantamine

357-70-0

Memantine 19982-08-2
Tarenflurbil 51543-40-9
Gantenerumab 89957-37-9
Pozanicline 103255-66-9
Lazabemide 103878-84-8
Linopirdine 105431-72-9
Cevimeline 107233-08-9
Besipirdine 119257-34-0
Donepezil 120014-06-4
Rivastigmine 123441-03-2
Xanomeline 131986-45-3
Tazomeline 131987-54-7
Sibopirdine 139781-09-2
Icopezil 145508-78-7
Talsaclidine 147025-53-4
Sabcomeline 159912-53-5
Leteprinim potassium 192564-13-9
Ladostigil 209394-27-4
Neramexane 219810-59-0
Semagacestat 425386-60-3
Aleplasinin 481629-87-2
Begacestat 769169-27-9
Sofinicline benzenesulfonate 876170-44-4
Solanezumab 955085-14-0

 

 

SALES SPECIFICATION

APPEARANCE

yellow crystalline powder
ASSAY

98.0% min

LOSS ON DRYING

2.0% min

HEAVY METALS

20ppm max

ARSENIC

1ppm max

SULFATED ASH

1.0% max

 

PACKING

 

 

PRICE

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