DIOSMIN

PRODUCT IDENTIFICATION

CAS RN

520-27-4

EINECS RN

208-289-7

FORMULA

C₂₈H₃₂O₁₅

MOLE WEIGHT

608.54

H.S CODE

SMILES

CLASSIFICATION

Flavone Glycoside

EXTRA NOTES

Diosmin is a semisynthetic drug (modified hesperidin), a member of the flavonoid family. It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, (Wikipedia).

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

yellow powder

MELTING POINT

274 C

BOILING POINT

DENSITY

SOLUBILITY IN WATER

Practically insoluble

Dissolves in dilute alkali hydroxides, practically insoluble in alcohol

VAPOR DENSITY

log P(octanol-water)

VAPOR PRESSURE

AUTOIGNITION TEMP

REFRACTIVE INDEX

FLASH POINT

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Diosmin

Google Scholar Search - Diosmin

Drug Information Portal (U.S. National Library of Medicine) - Diosmin

PubChem Compound Summary - Diosmin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Diosmin

http://www.ebi.ac.uk/ - Diosmin

http://www.ncbi.nlm.nih.gov/ - Diosmin

http://findarticles.com
Diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources or derived from the flavonoid hesperidin. Diosmin was first isolated in 1925 from Scrophularia nodosa, and first introduced as a therapeutic agent in 1969. Diosmin is considered to be a vascular-protecting agent used to treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. As a flavonoid, diosmin also exhibits anti-inflammatory, free-radical scavenging, and antimutagenic properties. Diosmin differs molecularly from hesperidin by the presence of a solid bond between two carbon atoms in diosmin's central carbon ring. Diosmin can be manufactured by extracting hesperidin from citrus rinds, followed by conversion of hesperidin to diosmin. Diosmin has been used for more than 30 years as a phlebotonic and vascular-protecting agent, and has recently begun to be investigated for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.

http://www.uhealth.net/
For the last 30 years, millions of European women have been using a doctor-prescribed citrus fruit extract to attain healthier, smoother, and shapelier legs. Now, US women have access to the same European wonder drug, available without a doctor’s prescription as a nutraceutical product, called micronized diosmin. Micronized diosmin has been clinically proven to produce healthier-looking legs by healing swollen ankles, spider and varicose veins, and leg ulcers. While current US drug treatments for cosmetic improvement in the legs have not achieved good clinical efficacy, micronized diosmin has enjoyed an outstanding 30-year record of research testing and success in Europe. Diosmin is a naturally occurring hesperidin bioflavonoid. Pharmaceutical grade diosmin is extracted from the rinds of sweet oranges. The sweet orange, a hybrid of the pomelo and tangerine, was originally cultivated in southeast Asia. It was then brought to Spain in the ninth century and later to Florida by Spanish explorers during the 1500s. The most clinically effective diosmin is micronized, which means it has undergone a scientifically controlled process to reduce the size of standard particles in order to increase its bio-availability and to achieve rapid relief of symptoms and to accelerate healing.2,3 For the estimated 12 to 25 million people in the United States who suffer with “cankles” (loss of definition between calves and ankles due to swelling) and unsightly and painful varicose veins and spider veins, micronized diosmin may offer a safe and effective non-surgical treatment option, oranges. The sweet orange, a hybrid of the pomelo and tangerine, was originally cultivated in southeast Asia. It was then brought to Spain in the ninth century and later to Florida by Spanish explorers during the 1500s. The most clinically effective diosmin is micronized, which means it has undergone a scientifically controlled process to reduce the size of standard particles in order to increase its bio-availability and to achieve rapid relief of symptoms and to accelerate healing.

SALES SPECIFICATION

APPEARANCE

yellow hygroscopic powder

ASSAY

90.0% min

WATER

6.0% max

SULFATED ASH

0.5% max

PARTICLE SIZE

75µm (100%)

MELTING POINT

260 ~ 265 C

HEAVY METALS

20ppm max

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

SAFETY INFORMATION

HAZARD OVERVIEW

May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed.

RISK PHRASES

SAFETY PHRASES

PACKING

Preserve in light-resistant and well-closed containers