SALICYLIC ACID

PRODUCT IDENTIFICATION

CAS NO. 69-72-7

SALICYLIC ACID

EINECS NO. 200-712-3
FORMULA HOC6H4COOH
MOL WT. 138.12
H.S. CODE 2918.21
TOXICITY Oral rat LD50: 891 mg/kg
SYNONYMS o-Hydroxybenzoic acid; Phenol-2-carboxylic acid;
Salonil; 2-Hydroxybenzoic acid; 2-Hydroxybenzenecarboxylic acid; 2-Carboxyphenol; o-Carboxyphenol; Acido O-idrossibenzoico (Italian); Acido Salicilico (Italian); 2-hydroxy-Benzoic Acid; o-Hydroxybenzoic Acid; 2-Hydroxybenzoic Acid; Kyselina 2-hydroxybenzoova (Czech); Kyselina Salicylova (Czech); Orthohydroxybenzoic Acid;
SMILES sodium salicylate ← sodium phenolate

CLASSIFICATION

CARBOCYCLIC CARBOXYLIC ACIDS

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 159 C
BOILING POINT 211 C
SPECIFIC GRAVITY 1.44
SOLUBILITY IN WATER Slight

SOLVENT SOLUBILITY

soluble in alcohol, ether, boiling water, sparingly soluble in chloroform
AUTOIGNITION

540 C

pH

2.4

VAPOR DENSITY 4.8
NFPA RATINGS Health: 0 Flammability: 1 Reactivity: 0
REFRACTIVE INDEX

 

FLASH POINT  
STABILITY Stable under ordinary conditions. Light sensitive.

GENERAL DESCRIPTION & APPLICATIONS

Salicylic Acid is a white crystalline powder or needle-shaped crystals with sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water; melts at 158°C. The sodium salt form (sodium salicylate) is common commercially, prepared from mainly sodium phenolate with carbon dioxide under heating and pressure. It contains both a hydroxyl and a carboxyl group, which react with either an acid or an alcohol. The carboxyl group forms esters with alcohols; e.g. methyl salicylate is formed with methanol, which used in food flavorings and preservatives; menthyl salicylate is formed with methanol, which is used in suntan lotions. The hydroxyl group reacts with acetic acid to form acetylsalicylic acid (called aspirin) which is the most widely common antiseptic and antipyretic agent. Phenyl salicylate (called salol) is formed with phenol, which is also used as an antiseptic and antipyretic agent. The sodium salt (Sodium salicylate), a shiny white powder, is used for antiseptics preparations and as a preservative. In addition to its analgesic and antipyretic properties, salicylic acid possesses keratinolytic properties and fungicidal properties. It ans its derivatives are used in the treatment of hyperkeratotic, dandruff, ichthyosis and psoriasis as well as in the treatment of fungal skin infections such as tinea. Para-Aminosalicylic acid (abbreviated PAS and PASA) is an analogue of para-aminobenzoic acid (abbreviated PABA) that inhibits folic acid synthesis in Mycobacterium tuberculosis and is bacteriostatic, inhibits growth and multiplication of the tubercle bacillus. Para-Aminosalicylic acid and its sodium salt (sodium p-Aminosalicylate) are bacteriostatic against mycobacteria and used in the treatment of tuberculosis; administered orally. Brand names are Tubasal, Nemasol Sodium and etc. Aminosalicylic acids are pharmaceutically active ingredients including anti-infectives against colds, flu, or other virus infections. Mesalamine (5-aminosalicylic acid, abbreviated 5-ASA) an active metabolite of sulfasalazine, used to treat inflammation of the rectum and lower colon, mild to moderate ulcerative colitis proctosigmoiditis, and proctitis. Para-Aminosalicylic acid (4-hydroxybenzoic acid) is used as an intermediate of bacteriostatic agent specially for parabens (alkyl esters of p-hydroxy benzoic acid) which used in food and personal care products as a preservative. It is applied in the production of liquid crystal polymers. It is also used as an intermediate of dyes, insecticides, pharmaceutical, pesticides and other chemical compounds. Salicylic Acid and its derivatives are important for the preparation of other pharmaceutical products, dyes, flavours, and preservatives. Topical keratolytic agents are beta hydroxy acids such as salicylic acid.

KERATOLYTIC AGENTS

Keratolytic

CAS RN

Acitretin 55079-83-9
Alcloxa 1317-25-5
Aldioxa 5579-81-7
Allantoin 97-59-6
Benzoyl peroxide 94-36-0
Dibenzothiophene 132-65-0
Etarotene 87719-32-2
Etretinate 54350-48-0
Isotretinoin 4759-48-2
Motretinide 56281-36-8
Nordihydroguaiaretic acid 500-38-9
Podofilox 518-28-5
Podophyllum resin 9000-55-9
Resorcinol 108-46-3
Resorcinol monoacetate 102-29-4
Salicylic acid 69-72-7
Sumarotene 84264-84-6
Sumarotene 105687-93-2
Tazarotene 118292-40-3
Tetroquinone 319-89-1
Tretinoin 302-79-4
SALES SPECIFICATION

BP GRADE

APPEARANCE

white to off-white crystalline powder
ASSAY 99.0% min

MELTING POINT

157 min

HEAVY METALS

20ppm max

WATER

0.5% max

ASH

0.1% max

LOSS ON DRYING

0.5% max

TECH GRADE

APPEARANCE

white to off-white crystalline powder
ASSAY 98.5% min

MELTING POINT

155 C

WATER

0.5% max

RESIDUE ON IGNITION

0.5% max

TRANSPORTATION
PACKING 25kgs in bag
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases: 24-41, Safety Phrases: 26-39