PIPERIDINE

PRODUCT IDENTIFICATION

CAS NO.

110-89-4

PIPERIDINE

EINECS NO.

203-813-0

FORMULA CH2(CH2)4NH
MOL WT. 85.15
H.S. CODE 2933.39
TOXICITY Oral rat LD50: 400 mg/kg
SYNONYMS Hexahydropyridine; Pentamethyleneimine; Azacyclohexane;
cyclopentimine; cypentil; hexazane; Piperidin (German);
RAW MATERIALS
 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE clear or slight yellow with pepper like odor
MELTING POINT -13 C
BOILING POINT 106 C
SPECIFIC GRAVITY 0.862
SOLUBILITY IN WATER Miscible
AUTOIGNITION  
pH 12.6
VAPOR DENSITY 3
NFPA RATINGS Health: 2 ; Flammability: 3 ; Reactivity: 3

REFRACTIVE INDEX

1.4534
FLASH POINT

15 C

STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Piperidine, hexahydropyridine, is a family of heterocyclic organic compound derived from pyridine through hydrogenation. It has one nitrogen atom in the cycle. It is a clear liquid with pepper-like aroma. It boils at 106 C, soluble in water, alcohol, and ether. The major application of piperidine is for the production of dipiperidinyl dithium tetrasulfide used as a rubber vulcanization accelerator. In pharmaceutical synthesis industry, it is a skeleton in some drugs such as  methylphenidate (central nervous system stimulant), budipine (antiparkinsonian drug) raloxifene (selective estrogen receptor modulator), minoxidil (an oral drug to treat high blood pressure). It is used as a special solvent in solid phase synthesis and a protecting group for peptide synthesis. Piperidine derivative compounds are used as intermediate to make crystal derivative of aromatic nitrogen compounds containing nuclear halogen atoms. Ring system compounds with nitrogen which have basic property playing important roles as cyclic component in industrial field such as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts, antioxidants and as a catalyst for silicone esters. They are used in manufacturing pharmaceuticals. Piperidine is listed as a Table II precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

SALES SPECIFICATION

APPEARANCE

clear to light yellow liquid
PURITY (G.C)

99.5% min

COLOR, APHA

10 max

SPECIFIC GRAVITY

0.857 - 0.867

MOISTURE (K.F) 0.1% max
TRANSPORTATION
PACKING 170kgs in drum
HAZARD CLASS 3 (Packing group : II)
UN NO.

2401

DESCRIPTION OF PYRIDINE
PYRIDINE, also called azabenzene and azine, is a heterocyclic aromatic tertiary amine characterized by a six-membered ring structure composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring (C5H5N). The simplest member of the pyridine family is pyridine itself. It is colorless, flammable, toxic liquid with a unpleasant odor, miscible with water and with most organic solvents, boils at 115 C. Its aqueous solution is slightly alkaline. Its conjugate acid is called pyridinium cation, C5H5NH+, used as a oxidation agent for organic synthesis.. Pyridine is a base with chemical properties similar to tertiary amines. Nitrogen in the ring system has an equatorial lone pair of electrons, that does not participate in the aromatic pi-bond. Its aqueous solution is slightly alkaline. It is incompatible and reactive with strong oxidizers and strong acids, and reacts violently with chlorosulfonic acid, maleic anhydride, oleum, perchromates, b-propiolactone, formamide, chromium trioxide, and sulfuric acid. Liquid pyridine easily evaporates into the air. If it is released to the air, it may take several months to years until it breaks down into other compounds. Usually, pyridine is derived from coal tar or synthesized from other chemicals, mainly acetaldehyde and ammonia. Pyridine compounds are found in nature. For example, nicotine from tobacco, ricinine from castor bean, pyridoxine or vitamin B and P products, alkaloids (such as coniine, piperine and nicotine), and etc. Some pyridine compounds consumed largely are;

Picoline : Three structural isomers of methyl pyridines (alpha, beta, gamma- positions)
Lutidine : Six structural isomers of dimethyl pyridines (2,3-, ,24-, 2,5-, 2,6-, 3,4-, 3,5- positions)
Collidine : Three structural isomers of trimethyl pyridines (2,3,5-, 2,3,6-, 2,4,6- positions)
Pyrimidine: Pyridine alteration containing nitrogen atoms at positions 1 and 3
Piperidine: Hexahydropyridine (saturated form)
Nicotinic acid: pyridine-3-carboxylic acid

Pyridine and its derivatives are very important in industrial field as well as in bio chemistry. Nucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). Three major pyrimidines in living systems are cytosine, thymine, and uracil. Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. Some pyridine system is active in the metabolism in the body. Certain nitrogenous plant products also have pyridine class compounds. They can be the parent compound of many drugs, including the barbiturates. Pyridine and its derivatives are used as solvents and starting material for the synthesis of target compounds such as insecticides, herbicides, medicines, vitamins, food flavorings, feed additives, dyes, rubber chemicals, explosives, disinfectants, and adhesives. Pyridine is also used as a denaturant for antifreeze mixtures, as a dyeing assistant in textiles and in fungicides.

PRICE

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