METHYLENE BLUE

PRODUCT IDENTIFICATION

CAS NO. 61-73-4 (Anhydrous)
7220-79-3 (Trihydrate)

METHYLENE BLUE 

EINECS NO. 200-515-2
FORMULA C16H18ClN3S
MOL WT. 319.85
H.S. CODE 3204.13.4500
TOXICITY Oral rat LD50: 1180 mg/kg
SYNONYMS Basic blue 9; Methylthioninium chloride; Swiss blue;
3,7-Bis(dimethylamino)-phenothiazin-5-ium chloride; p-Bis(dimethylamino)-phenothiazin- 5-ium chloride; C.I. 52015; Methylthioninium chloride; 3,7-Bis(dimethylamino)phenazathionium chloride; Tetramethylene Blue; Tetramethylthionine chloride; Urolene Blue; Methylene blue; Other RN: 1341-90-8, 6476-03-5, 105504-42-5, 121067-62-7, 12262-49-6, 167498-52-4, 97130-83-1
SMILES

c12c(nc3ccc(cc3[s+]1)N(C)C)ccc(N(C)C)c2.[ClH-]

CLASSIFICATION

 

EXTRA NOTES

EPA Pesticide Chemical Code 039505
water or alcohol have a deep blue color.  Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits Guanylate cyclase, and has been used to treat cyanide poisoning and to lower levels of Methemoglobin.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE dark green crystalline powder
MELTING POINT 190 C (Decomposes)
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 4.36E+04 mg/l
AUTOIGNITION  
pH  
VAPOR DENSITY  
NFPA RATINGS  
FLASH POINT

 

STABILITY Stable under ordinary conditions. Hygroscopic

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Methylene blue

Google Scholar Search - Methylene blue

Drug Information Portal (U.S. National Library of Medicine) - Methylene blue

PubChem Compound Summary - Methylene blue

KEGG (Kyoto Encyclopedia of Genes and Genomes)Methylene blue

http://www.ebi.ac.uk/Methylene blue

http://www.ncbi.nlm.nih.gov/Methylene blue

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank -
Methylene blue

Local:
Methylene blue, a methylated homologue of basic dye, is a cationic thiazine dye showing deep blue color in the oxidized state. It is a highly hygroscopic dark green crystalline powder having a bronze-like luster. It forms a reversible redox system with colorless leukomethylene blue (the reduced state of methylene blue). They exist in equilibrium. Methylene blue reduces the heme from methemoglobin to hemoglobin, but methemoglobin is produced when equilibrium is destroyed at high level of methylene blue. It is an electron donor or acceptor and free radical scavenger. It is clinically used to identify anatomic and pathologic structures to treat methemoglobinemia. It is used as a bacteriological in fresh frozen plasma. It is used to treat ich. It is used as a pathological stain and as a diagnostic aid in the detection of the premature rupture of fetal membranes and to identify separate amniotic sacs in multiple pregnancies. It is used as a biological and bacteriological stain, oxidation-reduction indicator as well.

SALES SPECIFICATION

APPEARANCE

dark green crystalline powder

DYE CONTENT

82.0% min

WATER

8 - 18.0%

SULFATED ASH

0.3% max

SOLUBILITY

430 (g/l in methanol)

HEAVY METALS

5ppm max

TRANSPORTATION
PACKING  
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 40, Safety Phrases: 24/25/36/37/45
BIOLOGICAL STAINS, INDICATORS

SAFETY INFORMATION

HAZARD OVERVIEW

Harmful if swallowed. Target Organ Effect, Harmful by ingestion., Irritant. Target Organs:Blood, Central nervous system, Eyes

GHS

 

SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H302-H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

22-36/37/38

SAFETY PHRASES

26-36