CELLULOSE ACETATE PHTHALATE

PRODUCT IDENTIFICATION
CAS NO. 9004-38-0

 

EINECS NO. unlisted
FORMULA  
MOL WT. 80,000 - 140,000
H.S. CODE 3912.90.0090
TOXICITY  
SYNONYMS Cellacefate; CAP; Celacefato; Cellacefato; Cellacefatum;
Cellulose acetate hydrogen phthalate; cellulose acetate hydrogen 1,2-benzenedicarboxylate; Cellulose Acetate Monophthalate; Cellulose Acetylphthalate; Cellulose Acetophthalate; monophthalic acid ester of hydroxypropyl methyl cellulose; Cellulose acetate phthalate; HPMCP; Hypromellose Phthalate; Acetyl phthalyl cellulose;  Cellacephate; Cellulose (acetylphtalate de); Cellulose acetate monophthalate; Cellulose acetate phthalate; Cellulose acetophthalate; Cellulose acetylphthalate; Cellulosi acetas phtalas; Cellulosi acetico-phthalas; Cellulosum; Acetylatum-phthalylatum; Cellulosum acetylphthalicum; Cellulose acetate 1,2-benzenedicarboxylate; Other RN: 8063-81-8, 9032-33-1, 37264-78-1, 55600-03-8
SMILES O([C@@H]1[C@H](O[C@@H](O*)[C@@H]([C@H]1O)OC(c1c(cccc1 )C(O)=O)=O)COC(C)=O)[C@H]1[C@@H]([C@H]([C@H](O*)[C@H] (O1)COC(C)=O)OC(c1c(cccc1)C(O)=O)=O)O

CLASSIFICATION

 Pharmaceutic aid

EXTRA NOTES

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white powder or flakes
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY

 

SOLUBILITY IN WATER swells to form viscosity colloidal solution.

SOLVENT SOLUBILITY

Soluble in most organic solvents, Insolube in hot water, alcohol

DECOMPOSITION

 

pH  
VAPOR DENSITY  
NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0
FLASH POINT

 

STABILITY Stable under ordinary conditions

APPLICATIONS

Wikipedia Linking

Material Safety Data Sheet

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Cellacefate

PubChem Compound Summary - Cellacefate

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Cellacefate

http://www.enerex.ca/
Applications in Pharmaceutical Formulation or Technology: Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. 1 - 8 Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment.  Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems or by direct compression. Concentrations generally used are 0.5-9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone. Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlled-release preparations. Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.

Local:
Hydroxypropyl Methylcellulose Phthalate is an enteric film coating material or a matrix binder in solid dosage forms. It is used as a viscosity control agent, gelling agent, film former, stabilizer, dispersant, lubricant, binder, emulsifying agents, and suspending agent. End applications include  adhesives and glues, agriculture, building materials, personal care products, detergents and surfactants, paints, printing inks,and coatings, pharmaceuticals, food products, polymerization and textiles.

SALES SPECIFICATION (BP/USP/EP)

APPEARANCE

 white to off-white powder or flakes

IDENTIFICATION

Conforms

SULFATED ASH

0.1% max

HEAVY METALS

10ppm max

VOLATILE IMPURITY

Conforms

VISCOSITY

45 - 90 cps

FREE ACID

3.0% max

WATER

5.0 max

ACETYL GROUP

21.5 - 26.0%

PHTHALOYL GROUP

30.0 - 36.0%

TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO. Not regulated
SAFETY INFORMATION

Hazard OVERVIEW

Not a dangerous substance

GHS

 
PRICE INFORMATION