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Piperazine is a
heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4
position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline
compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It
is used as a main ingredient of anthelmintics used to treat intestinal
roundworms (ascariasis) infection in human and poultry and to treat pinworms
(enterobiasis; oxyuriasis) by altering cell membrane permeability and causing
hyperpolarization of the membrane. Piperazine is a moiety in psychoactive
drugs. Certain piperazine derivatives are suspected of ecstasy substitutes.
Benzylpiperazine is bannaed in many countries. Benzylpiperazine has been used
as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an
important role in biological research and drug manufacturing industry including
the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic,
antiemetic and antimigraine agents. The piperazine ring and piperazine
derivatives are important cyclic components in industrial field as raw materials
for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators
for rubber, urethane catalysts and antioxidants.
N-Aminoethyl
piperazine has primary (R-NH2),
secondary (R-NH-R) and tertiary (R3-N) amine
in one molecule. It is used as an
intermediate to produce catalysts, pharmaceuticals, emulsifiers and corrosion
inhibitors and asphalt additives. The primary and secondary impart in curing
action. It is mainly used as an epoxy curing agent.
Common aliphatic amine class curing agents include:
- Diethylenetriamine
(CAS RN: 111-40-0)
- Trientine
(CAS RN: 112-24-3)
- N,N-Diethyltrimethylenediamine
(CAS RN: 104-78-9)
- Menthane diamine
(CAS RN: 80-52-4)
- Aminoethylpiperazine
(CAS RN: 140-31-8)
- 1,3-Xylenediamine
(CAS RN: 1477-55-0)
- Isophorone diamine
(CAS RN: 2855-13-2)
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