VILDAGLIPTIN

VILDAGLIPTIN

Synonyms. Vildagliptin; (2S)-(((3-Hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; Galvus; (2R)-1-(2-((3-Hydroxy-1- adamantyl)amino)acetyl)pyrrolidine-2-carbonitrile; 1-(2-((3-Hydroxy-1-adamantyl)amino) acetyl)pyrrolidine -2-carbonitrile; Xiliarx;

PRODUCT IDENTIFICATION
CAS RN	274901-16-5
EINECS RN
FORMULA	C₁₇H₂₅N₃O₂
MOLE WEIGHT	303.40
H.S CODE	2933.99.7500
SMILES	C1CC[C@H](C#N)N1C(=O)CNC12CC3CC(C1)(O)CC(C2)C3
CLASSIFICATION	Antidiabetic, Dipeptidyl-Peptidase IV Inhibitor, Protease Inhibitor
EXTRA NOTES	A potent, selective and orally bio-available dipeptidyl-peptidase IV inhibitor.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE.	white to off-white powder
MELTING POINT
BOILING POINT	148 - 152 C
DENSITY
SOLUBILITY IN WATER
SOLVENT SOLUBILITY
VAPOR DENSITY
log P(octanol-water)
VAPOR PRESSURE
AUTOIGNITION TEMP
pKa
REFRACTIVE INDEX
FLASH POINT	267 C

STABILITY AND REACTIVITY
STABILITY	Stable under normal conditions.
INCOMPATIBLE MATERIALS	Strong oxidizing agents
POLYMERIZATION	Has not been reported
NFPA RATINGS	Health: 0, Flammability:0, Reactivity: 0

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Vildagliptin

Google Scholar Search - Vildagliptin

Drug Information Portal (U.S. National Library of Medicine) - Vildagliptin

PubChem Compound Summary - Vildagliptin

Drug Bank - Vildagliptin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Vildagliptin

http://www.ebi.ac.uk/ - Vildagliptin

http://www.ncbi.nlm.nih.gov/ - Vildagliptin

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Vildagliptin

http://www.nature.com/
Dipeptidyl peptidase-4 (DPP-4) inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes DPP-4 inhibitors improve fasting and postprandial glycemic control without hypoglycemia or weight gain. This article focuses on the physiology, clinical pharmacology, tolerability, and clinical utility of the DPP-4 inhibitor sitagliptin in the management of type 2 diabetes.

http://clinical.diabetesjournals.org/
Sitagliptin is the first agent in a new category of medications, the dipeptidyl peptidase-IV (DPP-IV) inhibitors. It was recently approved in the United States for the management of hyperglycemia in patients with type 2 diabetes; vildagliptin, a second agent in this class, is likely to join it on the U.S. market soon. These compounds accentuate the activity of endogenously produced antihyperglyemic incretin hormones and are generally well tolerated. This article provides an overview of the pharmacology and clinical use of the DPP-IV inhibitors.

Local

APIs for the management of type II diabetes
Product	CAS RN.
Moxonidine	75438-57-2
Nateglinide	105816-04-4
Rivoglitazone	185428-18-6
Ingliforib	186392-65-4
Farglitazar	196808-45-4
Balaglitazone	199113-98-9
Tesaglitazar	251565-85-2
Vildagliptin	274901-16-5
Muraglitazar	331741-94-7
Peliglitazar	331744-64-0
Saxagliptin	361442-04-8
Edaglitazone Sodium	369631-81-2
Sergliflozin	408504-26-7
Remogliflozin etabonate	442201-24-3
Sodelglitazar	447406-78-2
Dapagliflozin	461432-26-8
Aleglitazar	475479-34-6
Piragliatin	625114-41-2
Sitagliptin phosphate	654671-77-9
Albiglutide	782500-75-8
Denagliptin tosylate	811432-66-3
Carmegliptin	813452-18-5
Indeglitazar	835619-41-5
Alogliptin	850649-61-5
Alogliptin benzoate	850649-62-6
Dutogliptin	852329-66-9
Saxagliptin	945667-22-1
Dapagliflozin	960404-48-2

SALES SPECIFICATION
APPEARANCE	white to off-white powder
IDENTIFICATION	Pass HPLC, IR
ASSAY	98.5% min
MELTING POINT	148 - 152 C
IMPURITY	1.5% max (total), 0.5% max (Individual)
LOSS ON DRYING	5.0% max
SULFATE	0.05% max
RESIDUE ON IGNITION	0.1% max
CHLORIDE	0.05% max
HEAVY METALS	10ppm max

TRANSPORT & REGULATORY INFORMATION
UN NO.	Not regulated
HAZARD CLASS
PACKING GROUP

SAFETY INFORMATION
HAZARD OVERVIEW	Avoid contact and inhalation. May causes eye irritation. May causes skin irritation. May cause gastrointestinal irritation. May causes respiratory tract irritation
HAZARD CODES
RISK PHRASES
SAFETY PHRASES	22-24/25

PACKING

PRICE INFORMATION