|
SEMUSTINE |
| Synonyms. Semustine; N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea; Methyl-CCNU; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; MeCCNU; Semustina; Semustinum; Methyllomustine; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; |
|
|
| PRODUCT IDENTIFICATION | |
|
CAS RN |
13909-09-6 |
|
EINECS RN |
|
|
FORMULA |
C10H18ClN3O2 |
|
MOLE WEIGHT |
247.72 |
|
H.S CODE |
2929.90.0000 |
|
SMILES |
C1(NC(N(CCCl)N=O)=O)CCC(C)CC1 |
|
CLASSIFICATION |
Antineoplastic agent, Alkylating agent, Nitrosourea |
|
EXTRA NOTES |
4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.(MeSH) Overall Carcinogenic Evaluation: Group 1 Other RN: 56748-54-0 |
|
|
| PHYSICAL AND CHEMICAL PROPERTIES | |
|
PHYSICAL STATE. |
white to yellow crystalline powder |
|
MELTING POINT |
63 ~ 65 C (Decomposes) |
|
BOILING POINT |
|
|
DENSITY |
1.158 |
|
SOLUBILITY IN WATER |
37 mg/l |
| SOLVENT SOLUBILITY | Soluble in methanol (50mg/ml), ethanol, lipids and nonpolar organic solvents. |
|
VAPOR DENSITY |
10.9 |
|
log P(octanol-water) |
3.3 |
|
VAPOR PRESSURE |
5.61E-06 mm Hg |
|
AUTOIGNITION TEMP |
|
| pH |
|
|
REFRACTIVE INDEX |
1.548 |
|
FLASH POINT |
|
|
|
| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
|
INCOMPATIBLE MATERIALS |
Strong oxidizing agents, Strong bases. Moisture |
| POLYMERIZATION |
Has not been reported |
|
NFPA RATINGS |
Health: 3, Flammability: 0, Reactivity: 0 |
|
|
| EXTERNAL LINKS & GENERAL DESCRIPTION |
|
Wikipedia Linking - Semustine Google Scholar Search - Semustine Drug Information Portal (U.S. National Library of Medicine) - Semustine PubChem Compound Summary - Semustine Drug Bank - Semustine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Semustine http://www.ebi.ac.uk/ - Semustine http://www.ncbi.nlm.nih.gov/ - Semustine http://toxnet.nlm.nih.gov/
|
|
|
| SALES SPECIFICATION | |
|
APPEARANCE |
white to yellow crystalline powder |
|
IDENTIFICATION |
positive (Test A,B) |
|
CONTENT |
98.5% ~ 101.5% |
| LOSS ON DRYING |
1.0% max |
|
HEAVY METALS |
20ppm max |
|
RELATED SUBSTANCES |
Total impurities:1.0% max, single impurity:0.5% max |
|
MELTING POINT |
63 ~ 65 C |
|
|
| TRANSPORT & REGULATORY INFORMATION | |
|
UN NO. |
2811 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | II |
|
|
| SAFETY INFORMATION |
|
|
HAZARD OVERVIEW |
Fatal if swallowed. Toxic in contact with skin or if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause cancer. May damage fertility or the unborn child. OSHA Hazards: Carcinogen, Toxic by inhalation., Highly toxic by ingestion, Toxic by skin absorption, Irritant, Reproductive hazard. Target Organs:Kidney, Bone marrow |
|
GHS |
|
|
SIGNAL WORD |
Danger |
|
PICTOGRAMS |
|
|
HAZARD STATEMENTS |
H300-H311-H315-H319-H331-H335-H350-H360 |
|
P STATEMENTS |
P201-P261-P264-P280-P301 + P310-P305 + P351 + P338 |
| EC DIRECTIVES |
|
| HAZARD CODES |
|
|
RISK PHRASES |
45-46-23/24/25-36/37/38 |
|
SAFETY PHRASES |
53-22-26-36/37/39-45 |
T|
|
| PACKING |
|
Preserve in light-resistant and well-closed containers |