PRISTIMERIN

Synonyms. Pristimerin; (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26 -trinoroleana-1(10), 3,5,7- tertraen- 29-oic acid methyl ester; Celastrol methylether; 3-Hydroxy-2-oxo-24-nor-D: A-friedooleana  -1(10), 3,5,7-tetraen-29-oic acid methyl ester; Celastrol methyl ester; Methyl (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9, 14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b- octahydropicene-2-carboxylate;

PRISTIMERIN

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

1258-84-0

EINECS RN

 

FORMULA

C30H40O4

MOLE WEIGHT

464.64

H.S CODE

2916.39.4500

SMILES

CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@] 3(CC [C@@] 5([C@H]4C[C@](CC5)

CLASSIFICATION

Triterpenoid

EXTRA NOTES

Biochem/physiol Actions - More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol. (SigmaAldrich)

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

orange crystal

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Insoluble

SOLVENT SOLUBILITY Soluble in DMSO, ethyl acetate

VAPOR DENSITY

 

log P(octanol-water)

 

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Pristimerin

Google Scholar Search - Pristimerin

Drug Information Portal (U.S. National Library of Medicine) - Pristimerin

PubChem Compound Summary - Pristimerin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Pristimerin

http://www.ebi.ac.uk/ - Pristimerin

http://www.ncbi.nlm.nih.gov/ - Pristimerin

 

SALES SPECIFICATION

APPEARANCE

orange crystalline powder

ASSAY

98.0% min

LOSS ON DRYING

3.0% max

HEAVY METALS

20ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

 
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

May be harmful by inhalation, ingestion, or skin absorption.

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

24/25

 

PACKING

Preserve in light-resistant and well-closed containers