PREGABALIN

PRODUCT IDENTIFICATION

148553-50-8

TOXICITY

H.S. CODE

Pregabalin; (S)-3-(Aminomethyl)-5-methylhexanoic acid;

(R-)-3-Isobutyl GABA; 3-Isobutyl GABA; (3S)-3-(Aminomethyl)-5-methylhexanoic acid; Lyrica;

C([C@@H](CC(C)C)CC(O)=O)N

CLASSIFICATION

Analgesic, Anticonvulsant

EXTRA NOTES

DEA No. 2782

PHYSICAL AND CHEMICAL PROPERTIES

1.35

REFRACTIVE INDEX

NFPA RATINGS

Health hazard: 2, Flammability: 0, Physical hazards: 0

AUTOIGNITION

FLASH POINT

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Pregabalin

PubChem Compound Summary - Pregabalin

Drug Bank -  Pregabalin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Pregabalin

http://www.ebi.ac.uk/ -  Pregabalin

http://www.ncbi.nlm.nih.gov/ -  Pregabalin

http://www.sciencedirect.com/
Gabapentin and pregabalin are structurally related compounds with recognized efficacy in the treatment of both epilepsy and neuropathic pain. The pharmacological mechanisms by which these agents exert their clinical effects have, until recently, remained unclear. The interaction of gabapentin and pregabalin with conventional antiepileptic and analgesic drug targets is likely to be modest, at best, and has been largely dismissed in favour of a selective inhibitory effect on voltage-gated calcium channels containing the α2δ-1 subunit. This mechanism is consistently observed in both rodent- and human-based experimental paradigms and may be sufficiently robust to account for much of the clinical activity of these compounds.

http://www.benthamscience.com/
Pregabalin and Libido- Case Reports: Pregabalin is a drug used in the treatment of neuropathic pain, partial seizures and generalized anxiety disorder. Pregabalin inhibits the release of the excess excitatory neurotransmitters, presumably by binding to the alpha 2 delta proteins of the widely distributed voltage dependent calcium channels in spine and brain. This mechanism is responsible for the anxyolitic, anticonvulsant and antinocioceptive effect. Libido is the term used to describe sexual desire or the psychic and emotional energy related to sexuality. In the accepted sense, libido refers specifically to the mental manifestations of the sexual instinct. Drugs used to treat anxiety disorders very often do have sexual side effects. Patients with generalized anxiety disorder can have an impaired libido due to the direct effect of anxiety.

N03AX:

APPEARANCE

IDENTIFICATION

passes Test IR, HPLC

ASSAY

98.5% min

9º ~ 11.5º

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.1% max

pH

6 ~ 8

R-FORM

0.5% max

HEAVY METALS

20ppm max

IMPURITY

1.0% max (total), 0.4% max (Individual Impurity)

HAZARD OVERVIEW

Irritant, Reproductive hazard, Teratogen

GHS

Danger

PICTOGRAMS

HAZARD STATEMENTS

H318-H361

P STATEMENTS

P280 + P351 + P338