MEPARTRICIN

MEPARTRICIN

Ipertrofan; Mepartricin; Mepartricina; Mepartricine; Mepartricinum; Methylpartricin; Orofungin; Tricandil; Tricangine; Partricin methyl ester;

MEPARTRICIN

PRODUCT IDENTIFICATION
CAS RN	11121-32-7, 12795-77-6
EINECS RN
FORMULA	C₆₀H₈₈N₂O₁₉
MOLE WEIGHT	1141.34
H.S. CODE	2941.90.1010
ACUTE TOXICITY	LD50 Oral - mouse: > 2,000 mg/kg
SMILES	C12(OC(C(C(C1)O)C(=O)OC)C(OC1[C@H]([C@H]([C@@H]([C@H](O1)C) O)N)O)CC=CC=CC=CC=CC=CC=CC=CC(C(OC(=O)CC(CC(=O)CC(CC(CC(C C(C2)O)O)O)O)O)C(CCC(CC(=O)c1ccc
CLASSIFICATION	Antibacterial agent, Anti-Infective agent, Antifungal, Antiparasitic, Antiprotozoal
EXTRA NOTES	Mepartricin is used in studies on sterol biosynthesis and bacterial cell membranes. It may be incorporated into liposomes. Polyene macrolide antibiotic with unknown composition. It is obtained from Streptomyces aureofaciens. It is used as an antifungal agent, an antiprotozoal agent, and in the treatment of benign prostatic hypertrophy.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	slightly yellow powder.
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STABILITY AND REACTIVITY
STABILITY	Stable under normal conditions
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NFPA RATING	Health: 1; Flammability: 0; Instability: 0;
TOXICOLOGICAL

POTENTIAL HEALTH EFFECTS
HAZARD OVERVIEW	No known OSHA hazards
EYE	May cause eye irritation.
SKIN	May be harmful if absorbed through skin. May cause skin irritation.
INGESTION	May cause irritation of the digestive tract.
INHALATION	May be harmful if inhaled. May cause respiratory tract irritation.
TARGET ORGANS	No data found.

TRANSPORT & REGULATORY INFORMATION
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EXTERNAL LINKS & GENERAL INFORMATION

Wikipedia Linking

Google Scholar Search

http://www.ncbi.nlm.nih.gov/
Mepartricin, the methyl ester of partricin, is a new polyene antibiotic with antifungal and antiprotozoal activity. The antitrichomonas activity in vitro is comparable to that of metronidazole, the widely used drug recently demonstrated to possess mutagenic activity and thus to be used with caution in therapy. Clinical investigations have shown that mepartricin can be successfully used in the topic treatment of vaginal trichomoniasis and candidiasis. The mutagenic activity of mepartricin has been evaluated using the Ames' test and compared to that of metronidazole. No mutagenic activity was detected for mepartricin. The drug can thus be proposed as a safer and efficient alternative to metronidazole.

http://www.ncbi.nlm.nih.gov/
An in-vitro comparison was made of the activity of mepartricin and amphotericin B against yeasts both in the presence and absence of pooled human plasma. The methods used included minimum inhibitory concentrations (MICs), liquid cultures and scanning electron microscopy (SEM). Mepartricin was found to be consistently more active than amphotericin B and to exhibit a partial inhibitory action over a wider range of concentrations below the MIC. In the presence of plasma, amphotericin B had increased activity but there was a slight reduction for mepartricin. By electron microscopy both drugs exhibited a rapid effect on Candida albicans and the cell membrane was found to be their primary target. Mepartricin was found to have the additional effect of causing a delayed separation of dividing cells and damage on both sides of the septum between mother and daughter cells. This suggests interference with the enzymatic mechanism of septum formation or chitin synthesis.

http://www.biosergen.no/
Polyene macrolides:Polyene macrolides have historically been the first antibiotics used in antifungal therapy. The discovery of nystatin and amphotericin in 1950s provided new opportunities for treatment of various fungal infections. Later, more than 200 other polyene macrolides with antifungal activity have been discovered, although only amphotericin B and nystatin have found substantial use , nystatin, candicidin, pimaricin, methyl partricin and trichomycin are currently being used in human therapy. In general, the polyene macrolides are rather toxic, and may cause such serious side-effects as renal tubular damage and thrombophlebitis, especially upon intravenous administration. Despite of that, broad spectrum of activity and low frequency of appearance of resistant pathogens make polyene antibiotics, like amphotericin B, the drug of choice when dealing with life-threatening systemic fungal infections. Polyene antibiotics display a unique mode of action by making the fungal cell membranes permeable to ions and other small molecules via polyene-ergosterol interactions.

Product	CAS RN.
Mepartricin	11121-32-7
Mepartricin sodium lauryl sulfate	59392-70-0
Mepartricin A	62534-68-3
Mepartricin B	62534-69-4

SALES SPECIFICATION
APPEARANCE	white to light yellow crystalline powder
CONTENT	95% min
HEAVY METALS	20ppm max

PRICE INFORMATION