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Bank - Melphalan
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Mechanism of Action: Melphalan, a mechlorethamine derivative, is an alkylating antineoplastic agent. It forms carbonium ions, resulting in DNA and RNA synthesis inhibition. It cross-links DNA strands and acts on both resting and rapidly dividing tumour cells.
Absorption: Variable absorption from the GI tract; absorption reduced by food (oral). Distribution: Rapid throughout body water. Protein-binding: 50-60%, mainly to albumin. Metabolism: Inactivated by hydrolysis. Excretion: Via urine (10%, as unchanged drug); 30-150 min (terminal half-life). MIMS Class: Cytotoxic Chemotherapy. ATC Classification: L01AA03 - Melphalan ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.