DIATRIZOIC ACID
Synonyms. Diatrizoic acid; Diatrizoate; 2,4,6-Triiodo-3,5-diacetamidobenzoic acid; 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid; 3,5-Diacetamido-2,4,6-triiodobenzoic acid; Acide amidotrizoique; Acidum amidotrizoicum; Acidum diacetylaminotrijodbenzoicum; Amidotrizoate; Amidotrizoic acid; Amidotrzoique (acide); DIAT; Diatrizoesaure; Odiston; Triombrin; Urografin acid; Urogranoic acid; Urotrast;

DIATRIZOIC ACID
 

PRODUCT IDENTIFICATION

CAS RN

 117-96-4, 50978-11-5 (Dihydrate)

EINECS RN

204-223-6

FORMULA

 C11H9I3N2O4

MOLE WEIGHT

 613.91

H.S CODE

 2924.29.0500

SMILES

 CC(=O)Nc1c(c(c(c(c1I)NC(=O)C)I)C(=O)O)I

CLASSIFICATION

 Contrast Media, Radiopaque medium

EXTRA NOTES

 A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white powder

MELTING POINT

 > 300 C

BOILING POINT

  

DENSITY

 

SOLUBILITY IN WATER

 Very slightly soluble
SOLVENT SOLUBILITY Soluble in dimethylformamide, alkali hydroxide solutions. Very slightly soluble in alcohol

VAPOR DENSITY

 

log P(octanol-water)

 1.37

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

n/a
POLYMERIZATION

Has not been reported

NFPA RATINGS

Health hazard: 1, Flammability: 0, Physical hazards: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Diatrizoic acid

PubChem Compound Summary - Diatrizoic acid

Drug Bank - Diatrizoate

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Diatrizoic acid

http://www.ebi.ac.uk/ -  Diatrizoate

http://www.ncbi.nlm.nih.gov/ - Diatrizoic acid

http://aem.asm.org/
 Iodinated X-ray contrast agents are considered to be nondegradable by microorganisms. The decomposition of the ionic X-ray contrast agents Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoic acid) and Iodipamide (3,3*-adipoyl-diimino-di(2,4,6-triiodobenzoic acid) and related triiodinated benzoates (Acetrizoate [3-acetylamino-2,4,6-triiodobenzoic acid] and Aminotrizoate [3-amino-2,4,6-triiodobenzoic acid]) by Trametes versicolor has been investigated. The fungus was able to transform all tested triiodinated benzoates cometabolically. During transformation of these compounds, iodide was released, but deiodination was not complete. T. versicolor liberated traces of 14CO2 from uniformly ring-14C-labeled Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoate). Various extracellular metabolites were detected during transformation of the different substances. In the transformation of Diatrizoate, the three main metabolites were identified as 3,5-di(acetamido)-2,6-diiodobenzoic acid, 3,5-di(acetamido)-2,4-diiodobenzoic acid, and 3,5-di(acetamido)-2-iodobenzoic acid, suggesting reductive deiodinations in steps as initial transformation steps.

 

 

SALES SPECIFICATION

APPEARANCE

white powder

IDENTIFICATION

passes test

ASSAY

98.0% - 102.0%

WATER

4.5% ~ 7.0%

RESIDUE ON IGNITION

0.1% max

IODINE

The toluene layer shows no red or pink color

IODIDE

0.02% max

FREE AR AMINE

0.05% max

HEAVY METALS

20ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD SYMBOL

 
PACKING GROUP  

 

PACKING

 

 

PRICE INFORMATION