CHLORPHENIRAMINE MALEATE

PRODUCT IDENTIFICATION

CAS NO. 132-22-9, 42882-96-2, 46970-45-0 (base)
25523-97-1 (D-form)
56343-98-7 (hydrochloride)
113-92-8, 7054-11-7 (maleate)
CHLORPHENIRAMINE
EINECS NO. 205-054-0, 247-073-7
FORMULA C16H19ClN2 · C4H4O4
MOL WT. 390.86

TOXICITY

Oral Rat LD50: 306mg/kg

H.S. CODE

2933.39.4100
SYNONYMS Chlorpheniramine maleate; Polaronil; Pyridamal 100;
Chlorphenamine hydrogen maleate; Carbinoxamide maleate; Medique chlorphen; Neorestamin; DL-2-(p-Chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridine maleate; DL-Chlorpheniramine maleate; Synistamin; Teldrin; Chlor-tripolon; Chlormene; Chloroprophenpyridamine maleate; Chlorpheniramine maleate; gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine (2Z)-2-butenedioate; Chlor-trimeton;
SMILES C(c1ccc(cc1)Cl)(c1ccccn1)CCN(C)C.C(=C\C(=O)O)\C(=O)O

CLASSIFICATION

Antihistaminic, Histamine H1 antagonist, Neurotransmitter agent, Antipruritic, Dermatologic agent

EXTRA NOTES

H1 Histamine receptor antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than Promethazine.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT

130 - 135 C

BOILING POINT

Decomposes

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
SOLVENT SOLUBILITY  
pKa 9.13 (base)
VAPOR DENSITY

 

log P (octanol-water) 3.38 (base)
HENRY LAW CONSTANT 4.07E-10 (atm-m3/mole at 25 C)
OH RATE CONSTANT 8.55E-11 (cm3/molecule-sec at 25 C Atmospheric)

REFRACTIVE INDEX

 

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Chlorphenamine

Material Safety Data Sheet

http://www.drugbank.ca/
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H
1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

http://otcsafety.org/
Chlorpheniramine is an antihistamine active ingredient available in over-the-counter (OTC) medicines that treats hay fever or other respiratory allergies. It may be written as chlorpheniramine or chlorpheniramine maleate, but it is the same active ingredient. Chlorpheniramine can be the only active ingredient in an allergy medicine or it can be found in medicines that not only relieve allergies, but other symptoms such as body aches and pains, or symptoms associated with the common cold.

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

passes Test IR

ASSAY

98.0% - 101.0%

LOSS ON DRYING

0.5%

RESIDUE ON IGNITION

0.2%

TRANSPORTATION
PACKING
 
HAZARD CLASS 6.1 (Packing group: III)
UN NO. 2811
SAFETY INFORMATION

GHS

 

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H301 Toxic if swallowed.

PRECAUTIONARY STATEMENTS

P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.

EC DIRECTIVES

 

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 

PRICE INFORMATION