CARMUSTINE

Synonyms. Carmustine; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; 1,3-Bis(2-chloroethyl)nitrosourea; 1,3-Bis(beta-chloroethyl)-1-nitrosourea; Bis(2-chloroethyl)1-nitrosourea; Bis(2-chloroethyl)nitrosourea; Bis-N,N'-(chloroethyl)nitrosourea; Bischlorethylnitrosourea; Bischlorethylnitrosurea; Bischloroethyl nitrosourea; Bischloroethylnitrosourea; Carmustina; Carmustinum; Nitrumon; Becenum; N,N'-Bis(2- chloroethyl)-N-nitrosourea; Becenun; Bicnu; Carmubris;

CARMUSTINE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

154-93-8

EINECS RN

205-838-2

FORMULA

 C5H9Cl2N3O2

MOLE WEIGHT

214.05

H.S CODE

 2924.19.1150

SMILES

 ClCCN(C(=O)NCCCl)N=O

CLASSIFICATION

Antineoplastic agent, Alkylating agent, Nitrosourea

EXTRA NOTES

 A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed) (MeSH)
Overall Carcinogenic Evaluation: Group 2A

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

yellowish semi-solid

MELTING POINT

30 C

BOILING POINT

 

DENSITY

1.46

SOLUBILITY IN WATER

Soluble in water up to 4 mg/ml

SOLVENT SOLUBILITY Soluble in 50% ethanol up to 150 mg/ml

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

1.548

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions. Decomposes rapidly in acid and in solution above pH 7

INCOMPATIBLE MATERIALS

Acids

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 3, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Carmustine

Google Scholar Search - Carmustine

Drug Information Portal (U.S. National Library of Medicine) - Carmustine

PubChem Compound Summary - Carmustine

Drug Bank -  Carmustine

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Carmustine

http://www.ebi.ac.uk/ - Carmustine

http://www.ncbi.nlm.nih.gov/ - Carmustine

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Carmustine

http://www.cedars-sinai.edu/
Carmustine and lomustine are lipid soluble drugs: penetrate the nervous system ( treat central nervous system malignancies, optic and neurological complications were reported) • Used also for treating malignant lymphomas, melanomas and some GIT tumors • Myelosuppression is the dose-limiting toxicity • Cause nausea and vomiting • Long term use of carmustine may cause pulmonary toxicity

 

SALES SPECIFICATION

APPEARANCE

yellowish semi-solid

IDENTIFICATION

positive (Test A,B)

CONTENT

98.0% ~ 101.0%
LOSS ON DRYING

2.0% max

HEAVY METALS

20ppm max

MELTING POINT

30 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP II

 

SAFETY INFORMATION

HAZARD OVERVIEW

Fatal if swallowed. May cause cancer. May damage fertility or the unborn child. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be fatal if swallowed.

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H300-H350-H360

P STATEMENTS

P201-P264-P301 + P310-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

T+

RISK PHRASES

45-46-60-61-28

SAFETY PHRASES

 53-22-36/37/39-45

 

PACKING

Preserve in light-resistant and well-closed containers