SODIUM p-AMINOSALICYLATE

PRODUCT IDENTIFICATION
CAS NO. 133-10-8 (Base)
6018-19-5 (Dihydrate)

SODIUM p-AMINOSALICYLATE
EINECS NO. 205-091-2
FORMULA C7H6NNaO3·2H2O
MOL WT. 211.15

H.S. CODE

 2198.23

TOXICITY

  
SYNONYMS Sodium P.A.S.; Tubasal; Sodium para-aminosalicylate;
4-Amino-salicylic acid Sodium salt; 4-Amino-2-hydroxybenzoic acid, sodium salt; Natrium-4-aminosalicylat (German); 4-Aminosalicilato de sodio (Spanish); 
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 250 - 254 C
BOILING POINT  
SPECIFIC GRAVITY > 1.0
SOLUBILITY IN WATER soluble (slightly soluble in alcohol)
pH 6.5 - 8.5 (2%)
VAPOR DENSITY

 
AUTOIGNITION  

REFRACTIVE INDEX

 
NFPA RATINGS Health: 2; Flammability: 0; Reactivity: 0
FLASH POINT

 
STABILITY Stable under normal conditions. Light, moisture sensitive.

GENERAL DESCRIPTION  & APPLICATIONS
Salicylic Acid is a white crystalline powder or needle-shaped crystals with sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water; melts at 158°C. The sodium salt form (sodium salicylate) is common commercially, prepared from mainly sodium phenolate with carbon dioxide under heating and pressure. It contains both a hydroxyl and a carboxyl group, which react with either an acid or an alcohol. The carboxyl group forms esters with alcohols; e.g. methyl salicylate is formed with methanol, which used in food flavorings and preservatives; menthyl salicylate is formed with methanol, which is used in suntan lotions. The hydroxyl group reacts with acetic acid to form acetylsalicylic acid (called aspirin) which is the most widely common antiseptic and antipyretic agent. Phenyl salicylate (called salol) is formed with phenol, which is also used as an antiseptic and antipyretic agent. The sodium salt (Sodium salicylate), a shiny white powder, is used for antiseptics preparations and as a preservative. In addition to its analgesic and antipyretic properties, salicylic acid possesses keratinolytic properties and fungicidal properties. It ans its derivatives are used in the treatment of hyperkeratotic, dandruff, ichthyosis and psoriasis as well as in the treatment of fungal skin infections such as tinea. Para-Aminosalicylic acid (abbreviated PAS and PASA) is an analogue of para-aminobenzoic acid (abbreviated PABA) that inhibits folic acid synthesis in Mycobacterium tuberculosis and is bacteriostatic, inhibits growth and multiplication of the tubercle bacillus. Para-Aminosalicylic acid and its sodium salt (sodium p-Aminosalicylate) are bacteriostatic against mycobacteria and used in the treatment of tuberculosis; administered orally. Brand names are Tubasal, Nemasol Sodium and etc. Aminosalicylic acids are pharmaceutically active ingredients including anti-infectives against colds, flu, or other virus infections. Mesalamine (5-aminosalicylic acid, abbreviated 5-ASA) an active metabolite of sulfasalazine, used to treat inflammation of the rectum and lower colon, mild to moderate ulcerative colitis proctosigmoiditis, and proctitis. Para-Aminosalicylic acid (4-hydroxybenzoic acid) is used as an intermediate of bacteriostatic agent specially for parabens (alkyl esters of p-hydroxy benzoic acid) which used in food and personal care products as a preservative. It is applied in the production of liquid crystal polymers. It is also used as an intermediate of dyes, insecticides, pharmaceutical, pesticides and other chemical compounds. Salicylic Acid and its derivatives are important for the preparation of other pharmaceutical products, dyes, flavours, and preservatives.
SALES SPECIFICATION

APPEARANCE

 white crystalline powder
PURITY

99.0% min
SOLUTION CLARITY

pass

pH

 6.5 - 8.5 (2%)

CHLORIDE

0.06% max

SULFATE

0.01% max

LOSS ON DRYING

16.0 - 18.0%

HEAVY METAL

10ppm max

ARSENIC

2ppm max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 22-36/37/38, Safety Phrases: 24/25
AMINOSALICYLIC ACID DERIVATIVES

Product

CAS RN
4-Acetamidosalicylic acid 50-86-2
N-Acetyl-5-aminosalicylic acid 51-59-2
Chloroquine 4-acetaminosalicylate 58-77-5
4-Aminosalicylic acid 65-49-6
Mesalamine 89-57-6

Sodium p-aminosalicylate

133-10-8

Phenyl-4-aminosalicylate

133-11-9
Calcium p-aminosalicylate 133-15-3
Aminosalicylate Potassium 133-09-5
Hydroxyprocaine 487-53-6
Hydroxytetracaine 490-98-2

Calcium benzamidosalicylate

528-96-1
Bronchocain 528-97-2
Oxyprocain hydrochloride 551-36-0
3-Aminosalicylic acid 570-23-0
Pasiniazid 2066-89-9
Pheniramine aminosalicylate 2508-73-8
Pasomycin 3144-30-7
Pheniramine 4-aminosalicylate 3269-83-8
Vadrine 3547-60-2
Methyl p-aminosalicylate 4136-97-4

4-Methoxy phenyl 4-aminosalicylate

4465-61-6
Isopropyl p-aminosalicylate 6018-21-9
Aminosalicylate sodium 6018-19-5
Ethyl p-aminosalicylate 6059-17-2
5-Aminosalicylic acid hydrochloride 6291-36-7
p-Aminosalicylic acid hydrazide 6946-29-8
2-Hydroxyethyl p-aminosalicylate 14510-00-0
Hydroxynovocaine p-aminosalicylate 15767-73-4
2-Chloroethyl p-aminosalicylate 16987-14-7
Salicaine hydrochloride 17284-75-2

4-(Diethylamino)salicylaldehyde

17754-90-4
Sodium 5-aminosalicylate 35589-28-7
Poly(N-acryloyl-4-aminosalicylic acid) 39839-48-0
Poly(N-acryloyl-5-aminosalicylic acid) 39839-49-1
Methyl 5-aminosalicylate 42753-75-3
5-Aminosalicylic acid-O-sulfate sodium salt 49860-08-4
3-Aminosalicylic acid 51481-17-5
4-Aminosalicylic acid oxine 52224-16-5
N-Methacryloyl-5-aminosalicylic acid 53193-87-6
Di-8-oxyquinoline-N-aminosalicylic acid 55720-09-7

3-Fluorophenyl 4-aminosalicylate

56356-26-4

4-Fluorophenyl 4-aminosalicylate

56356-27-5

3-Methoxy phenyl 4-aminosalicylate

56356-18-4

4-Aminosalicylic acid 4-isopropyl ester

56356-19-5

4-Aminosalicylic acid 2-isopropyl ester

56356-20-8

3-Aminophenyl 4-aminosalicylate

56356-23-1

4-Tolyl 4-aminosalicylate

56356-15-1

2-Fluorophenyl 4-aminosalicylate

56356-25-3

2-Methoxy phenyl 4-aminosalicylate

56356-17-3

2-Tolyl 4-aminosalicylate

56356-13-9

2-Chlorophenyl 4-aminosalicylate

56356-28-6

4-Chlorophenyl 4-aminosalicylate

56356-30-0

3-Chlorophenyl 4-aminosalicylate

56356-29-7

3-Tolyl 4-aminosalicylate

56356-14-0

4-aminophenyl 4-aminosalicylate

56356-24-2
5-Chloro-3'-nitro-4'-cyclohexylaminosalicylanilide 62450-33-3
4-Aminosalicylaldehyde thiosemicarbazone 63992-66-5
Acetyl-4-dimethylaminosalicylic acid 74152-38-8
p-Butylaminosalicylic acid 2-(diethylamino)cyclohexyl ester hydrochloride 78280-34-9
2-(Dimethylamino)ethyl p-aminosalicylate 78280-32-7
p-Butylaminosalicylic acid 2-(dimethylamino)cyclohexyl ester hydrochloride 78280-35-0
p-Butylaminosalicylic acid 1-methyl-4-piperidyl ester hydrochloride 78280-36-1
p-Aminosalicylic acid 2-(diethylamino)cyclohexyl ester hydrochloride 78280-30-5
p-Aminosalicylic acid 2-(dimethylamino)cyclohexyl ester hydrochloride 78280-31-6
p-Aminosalicylic acid 1-methyl-4-piperidyl ester hydrochloride 78280-33-8
p-Aminosalicylic acid 1-ethyl-4-piperidyl ester hydrochloride 78308-36-8
p-Butylaminosalicylic acid 1-ethyl-4-piperidyl ester hydrochloride 78308-37-9
3-Aminosalicylic acid hydrochloride 83860-30-4
Bis(4-aminosalicylato-O1,O2)magnesium 94233-03-1
5-Aminosalicylic acid-O-sulfate potassium salt 96143-97-4
Acetyl 4-aminosalicylic acid 102338-89-6
sec-Butyl p-aminosalicylate 102338-91-0
4-Butylaminosalicylic acid 3-piperidinopropyl ester dihydrochloride 102338-95-4
4-Aminosalicylic acid 3-(diethylamino)propyl ester hydrogen phosphate 102366-70-1
Methyl 5-aminosalicylate hydrochloride 110065-66-2
N-Glucopyranosyl-5-aminosalicylic acid 123135-21-7
5-(2,5-Dihydroxybenzylamino)-2-hydroxybenzoic acid 125697-93-0

5-(2,5-Dihydroxybenzylamino)-2-hydroxybenzoic acid

125697-93-0

N,N'-Terephthalylidenebis(4-aminosalicylic acid)

135463-15-9
Bis(diphenyl(4-aminosalicylate)tin)oxide 142785-15-7
Bis(di-n-butyl(4-aminosalicylate)tin)oxide 142785-14-6