PRODUCT IDENTIFICATION

CAS NO.

H.S. CODE

TOXICITY

c1ccc2c(c1)c(c[nH]2)CCN

CLASSIFICATION

Tryptamine

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

REFRACTIVE INDEX

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

USA.gov - Tryptamine

Wikipedia Linking - Tryptamine

Google Scholar Search - Tryptamine

Drug Information Portal (U.S. National Library of Medicine) - Tryptamine

PubChem Compound Summary - Tryptamine

Drug Bank -  Tryptamine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Tryptamine

http://www.ebi.ac.uk/chebi/ -  Tryptamine

http://www.ncbi.nlm.nih.gov/ -  Tryptamine

Material Safety Data Sheet - Tryptamine

EPA - Substance Registry Services - Tryptamine

Local:
Tyramine [4-(2-Aminoethyl)phenol] is a monoamine compound of 4-hydroxy phenethylamine. It is derived from tyrosine, an amino acid (protein building block) that is the precursor of norepinephrine. It, through its effect on neurotransmitters, may affect several health conditions, including Parkinson's disease, depression, alcohol withdrawal support, and Phenylketonuria. (PKU). Tyramine is naturally found in plant and animal tissues, certain cheeses and ergot or produced synthetically. It is metabolized by monoamine oxidase. Tyramine or its derivatives can be used in pharmaceutical industry such as:

• Sympathomimetic or adrenergic drugs themselves or intermediate of them.
• Intermediate for bezafibrate used in the treatment of high cholesterol levels.
• Determination of peroxide activity in the fluorescence enzyme immunoassay for insulin.
• False transmitter.

Tryptamine [3-(2-Aminoethyl)indole] is a biologically important monoamine compound derived  by the decarboxylation of tryptophan, indole side chain amino acid. In addition to its function to build the structure of protein, tryptophan is a precursor for neurotransmitter and neurohormone. Tryptamine (biological monoamine) effects vasoconstriction by causing the release of norepinephrine at postganglionic nerve endings. Several mental disorders and health conditions are explained as due to either an excess or deficiency of monoamines. There are many natural tryptamines in both animal and plant as well as synthetics modified by chemical constituents and substituted at appropriate positions in the motif. Common tryptamine class compounds include;

• Bufotenine (CAS #: 487-93-4): (5-Hydroxy-N,N-dimethyltryptamine, pressor agent, epinephrine-like.
• DMT (CAS #: 61-50-7): N,N-Dimethyltryptamine, a psychedelic and hallucinogenic.
• Luzindole (CAS #: 117946-91-5): N-Acetyl-2-benzyltryptamine
• Melatonin (CAS #: 73-31-4, 8041-44-9): N-Acetyl-5-methoxytryptamine, biological clock hormone.
• Psilocin: 4-Hydroxy-N,N-dimethyltryptamine.
• Psilocybin (CAS #: 520-52-5): 4-Phosphoryloxy-N,N-dimethyltryptamine, a hallucinogenic.
• Serotonin (CAS #: 50-67-9): 5-Hydroxytryptamine, a vasoconstrictor.
• Sumatriptan( CAS #: 103628-46-2) 4-Hethylaminosulfonyl-N,N-dimethyltryptamine, selective serotonin antagonist used in the treatment of migraine headache.

APPEARANCE

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