TRETINOIN

PRODUCT IDENTIFICATION
CAS NO. 302-79-4

TRETINOIN
EINECS NO. 206-129-0
FORMULA C20H28O2
MOL WT. 300.44

H.S. CODE

  

TOXICITY

  
SYNONYMS all-trans-Vitamin A acid; all trans-beta-Retinoic acid;
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; all-e-Retinoic acid; All-trans retinoic acid; all-trans-Tretinoin; all-trans-vitamin A1 acid; beta-All-trans-Retinoic Acid; beta-RA; beta-Retinoic acid; Retin-A; Retinoic acid; trans-Retinoic Acid; Tretinoino; Tretinoinum; Vitamin A acid; Tretinoino; Trétinoine;
SMILES

 

CLASSIFICATION

 VITAMINS /

GENERAL DESCRIPTION OF VITAMIN A

A fat-soluble vitamin, found in two principal forms; retinol and certain carotenoids in nature and produced synthetically. Retinol, important in vision and bone growth, is found only in animal sources. A family of carotenoids are found in green leafy vegetables and in brightly yellow colour fruits and vegetables. The best known form of carotenoid is beta-carotene which is converted to retinol in the body only when it is needed. One molecule of beta-carotene is splitted into two molecules of vitamin A and thus Beta-carotene is called Provitamin A. Beta-carotene, like other carotenoids, is recognized as an important antioxidant. Vitamin A is essential to skeletal growth, normal reproductive function, and maintenance of epithelial tissue. One form, retinal (vitamin A aldehyde) is a component of photoreceptor pigment in the retina of the eye. The deficiency of vitamin A can lead to eye disorders. Vitamin A is also known as antiinfective vitamin and antixerophthalmic vitamin. Retinoic acid, belongs to the group vitamin A, is an oxidized derivative of retinol, which plays a role in the development and growth of bone, in the regulating epithelial cell structure, and eyesight. Retinol is taken in a precursor form of  retinyl esters from animal foods like milk and eggs. The body cells convert precursors to retinol (a 20-carbon primary alcohol), and then the de-esterified alcohol can be converted to metabolically active retinal (the aldehyde of retinol) and retinoic acid (the oxidized form of retinol) formed by carboxylation of retinal. The retinal is used in vision functions as a component of photoreceptor pigment in the retina of the eye, whereas retinoic acid plays role in non-vision functions - regulating the growth and differentiation of normal and malignant cells. Accordingly, retinoic acid is useful as an ingredient in the treatment of acne medicinally. In pharmacology, tretinoin means all-trans retinoic acid; 13-cis isomer is called isotretinoin. Tretinoin is used to induce maturation of acute promyelocytic leukemia cells in culture and in the treatment of disorders of keratinization topically, and orally in the treatment of acute promyelocytic anemia as an antineoplastic. Isotretinoin inhibits the secretion of sebum and alters the lipid composition of the skin surface. It is used systemically for treatment of severe cystic and conglobulate acne.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to light-orange crystalline
MELTING POINT 180 - 181 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 Health: 1 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION AND APPLICATIONS
Retinoic acid, belongs to the group vitamin A, is an oxidized derivative of retinol, which plays a role in the development and growth of bone, in the regulating epithelial cell structure, and eyesight. Retinol is taken in a precursor form of  retinyl esters from animal foods like milk and eggs. The body cells convert precursors to retinol (a 20-carbon primary alcohol), and then the de-esterified alcohol can be converted to metabolically active retinal (the aldehyde of retinol) and retinoic acid (the oxidized form of retinol) formed by carboxylation of retinal. The retinal is used in vision functions as a component of photoreceptor pigment in the retina of the eye, whereas retinoic acid plays role in non-vision functions - regulating the growth and differentiation of normal and malignant cells. Accordingly, retinoic acid is useful as an ingredient in the treatment of acne medicinally. In pharmacology, tretinoin means all-trans retinoic acid; 13-cis isomer is called isotretinoin. Tretinoin is used to induce maturation of acute promyelocytic leukemia cells in culture and in the treatment of disorders of keratinization topically, and orally in the treatment of acute promyelocytic anemia as an antineoplastic. Isotretinoin inhibits the secretion of sebum and alters the lipid composition of the skin surface. It is used systemically for treatment of severe cystic and conglobulate acne.

Molecular compounds of Retinoic acid

Product CAS RN
Retinol 68-26-8
Retinol palmitate 79-81-2
3,4-Didehydro-all-trans-retinol 79-80-1
Retinal 116-31-4
Retinol acetate 127-47-9
Tretinoin 302-79-4
Methyl retinoate 339-16-2
Retinoyl glucuronide 401-10-5
Dehydroretinal 472-87-7
Hepaxanthin 512-39-0
9-cis-Retinal 514-85-2
Retinyl stearate 631-87-8
Retinol oleate 631-88-9
Retinyl linoleate 631-89-0
5,6-Epoxyretinal 739-13-9
Anhydrovitamin A 1224-78-8
13-cis-Retinol 2052-63-3
5,8-Monoepoxyretinoic acid 3012-76-8
Oxenin 3230-75-9
Ethyl 12-fluororetinoate 3887-00-1
Ethyl retinoate 3899-20-5
3,4-Didehydroretinoic acid 4159-20-0
Isotretinoin 4759-48-2
Alitretinoin 5300-03-8
9,13-Retinoic acid 5352-74-9
12-Carboxyretinoic acid 6703-19-1
3-Hydroxy-anhydroretinol 6890-94-4
3-Hydroxyretinal 6890-91-1
3-Hydroxyretinol 6890-93-3
trans-3-Retinylidene-2,4-pentanedione 6991-16-8
Retinyl propionate 7069-42-3
3-Hydroxyretinal oxime 7163-02-2
Methyl 5,6-epoxyretinoate 7432-30-6
12-Hydroxyretinoic acid gamma-lactone 10035-29-7
Provitamin A 11103-57-4
5,6-Epoxyretinoic acid 13100-69-1
Sodium retinoate 13497-05-7
Retinylglucuronide 16639-19-3
Retinaloxime 17672-05-8
4-Hydroxyretinal 18344-42-8
5,6-Dihydroretinal 19907-28-9
5,6-Epoxy-3-dehydroretinal 20008-03-1
3,4-Didehydroretinyl acetate 20008-04-2
Retinyl pivalate 20559-05-1
Retinamide 20638-84-0
9-cis-Retinol 22737-97-9
Retinylglucose 29880-05-5
all-trans-5,6-Dihydro-3,4-didehydro-5,6-epoxyretinoic acid 31979-12-1
Retinyl methyl ether 32450-56-9
4-Oxoretinaldehyde 33532-44-4
N,N-Diethylretinamide 33631-53-7
Vitamin A acid ethylamide 33631-41-3
N-(Butyl)retinamide 33631-44-6
N-(2-Hydroxyethyl)retinamide 33631-47-9
N-Phenylretinamide 33631-48-0
13-cis-Retinyl acetate 34356-31-5
Retinylphosphate galactose 35795-65-4
N-Retinylidene-n-butylamine 36076-04-7
4-Oxoretinoic acid 38030-57-8
Tocopheryl retinoate 40516-49-2
Tretinoin tocoferil 40516-48-1
11,12-Dihydroretinal 41889-27-4
trans-Retinylamine 43219-27-8
N-Retinyl phthalimide 43219-26-7
N-Acetylretinylamine 43219-29-0
S-N-Retinylidene-alpha-(1-naphthyl)ethylamine 51038-73-4
Methyl 7,8-dihydroretinoate 51077-51-1
7,8-Dihydroretinoic acid 51077-50-0
alpha-Retinoic acid 52978-64-0
alpha-Retinyl acetate 53250-57-0
4-(Carboethoxyphenyl)retinamide 53839-71-7
Retinol phosphate 53859-19-1
Etretinate 54350-48-0
Trimethylmethoxyphenyl-N-ethyl retinamide 54757-59-4
Acitretin 55079-83-9
Mannosylretinylphosphate 55722-25-3
Retinochrome 56274-73-8
beta-Retinyl sulfone 58970-49-3
Retinal acetylhydrazone 61630-48-6
4-Oxoretinol 62702-55-0
18-Hydroxyretinoic acid 63531-93-1
Retinol, acetate tritium 64536-04-5
Fenretinide 65646-68-6
Tylosin, sulfamethazine, retinol mixture 65702-93-4
all-trans-(11,12-3H2)Retinoic acid 66052-75-3
4-Hydroxyretinoic acid 66592-72-1
15-Methyl retinone 67517-37-7
15-Methylretinol 67517-42-4
15-Dimethylretinol 67517-39-9
13-cis-Retinaloxime 67890-48-6
11-cis-Retinaloxime 67999-43-3
14-Fluororetinal 68200-23-7
all-trans-2-Retinylidene-1,3-cyclopentanedione 70359-69-2
Retinylidene dimedone 70424-15-6
all-trans-(Carboxyl-14C)retinoic acid 70544-96-6
all-trans-(10,11-3H2)-Retinoic acid 70572-94-0
N-(Carboxymethyl)retinamide 71407-30-2
4-Oxo-13-cis retinoic acid 71748-58-8
Glucopyranosyl retinoate 71869-12-0
7,8-Dihydrorhodopsin 72535-16-1
all-trans-2-Retinylidene-1,3-cyclooctanedione 73685-26-4
all-trans-2-Retinylidene-5-p-methoxyphenyl-1,3-cyclohexanedione 73685-21-9
N-(4-Carboxyphenyl)retinamide 74193-17-2
N-Benzoylretinylamine 74193-18-3
7,8-Dehydroretinoic acid 74193-14-9
Retinyl thio ether 74193-12-7
Phenyl retinal 75001-15-9
N-(3-Hydroxypropyl)retinamide 75664-71-0
N-(2,3-Dihydroxypropyl)retinamide 75664-72-1
N-(4-Hydroxybutyl)retinamide 75664-74-3
N-(4-Pivaloyloxyphenyl)retinamide 75664-77-6
5,6-Dihydroxyretinoic acid methyl ester 75664-64-1
N-(2-Hydroxypropyl)retinamide 75664-84-5
Retinyl phenyl ether 75664-68-5
N-(1H-Tetrazol-5-yl)retinamide 75664-79-8
13-cis-N-Ethylretinamide 75686-04-3
13-cis-N-(4-Hydroxyphenyl)retinamide 75686-07-6
13-cis-N-(1H-Tetrazol-5-yl)retinamide 75686-08-7
13-cis-N-(2-Hydroxyethyl)retinamide 75686-05-4
N-(4-Propionyloxyphenyl)retinamide 75858-21-8
5,6-Dihydro-1,1,5,9,13-desmethylretinal 76080-85-8
all-trans-(11-3H)-Retinoic acid 77096-84-5
Ethyl-all-trans-4-(2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3- butadien-1-yl)benzoate 77837-56-0
beta-D-Glucopyranuronic acid, 1-(13-cis-retinoate) 78147-42-9
Solacy 79215-58-0
N-(4-Methoxyphenyl)retinamide 79965-10-9
N-(4-Hydroxyphenyl)retinamide-O-glucuronide 79982-82-4
5,6-Epoxyretinylphosphate 80134-56-1
12-O-Retinoylphorbol-13-acetate 80188-99-4
Phloretinyl-3'-benzylazide 80860-95-3
Retinyl bromoacetate 81112-43-8
5,6-Epoxyretinoyl glucuronide 81164-05-8
3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid 81485-25-8
Retinotaurine 81957-68-8
3-Diazirinophenylretinal 83374-72-5
Retinoyl fluoride 83802-77-1
12-Hydroxymethylretinoic acid delta-lactone 83860-24-6
13-cis-N-Butylretinamide 84680-30-8
13-cis-N-(4-Hydroxybutyl)retinamide 84680-31-9
Retinol 5-oxo-L-proline, ester 85026-82-0
Retinyl hexadecyl ether 85563-59-3
Perhydromonoeneretinyl phosphate 85733-82-0
Retinyl cyclopentanecarboxylate 88641-45-6
Retinyl heptanoate 88641-44-5
trans-Retinoyl chloromethane 88981-45-7
4,4-Difluororetinoic acid 90660-20-1
4,4-Difluororetinyl palmitate 90660-23-4
4,4-Difluororetinyl acetate 90660-22-3
4,4-Difluororetinol 90660-21-2
Retinylidene methylnitrone 91488-26-5
4-Azidoretinol 92484-22-5
N-(4-Aminosulfonylphenyl)retinamide 93449-27-5
7,10-Dihydro-10-hydroxyretinol acetate 93820-51-0
3-Dehydroretinol palmitate 95632-86-3
Perhydroretinol 96304-50-6
N-Retinoylphenylalanine 97885-88-6
cis-Retinoic acid 97950-17-9
9,10-Dihydroretinoic acid 98299-56-0
Retinal(O-ethyl)oxime 99794-88-4
Plethoryl 100216-56-6
6-(5-Azido-5,6,7,8-tetrahydro-5,8,8-trimethyl-2-naphthalenyl)-2- naphthalenecarboxylic acid 101705-41-3
6-(5-Azido-5,6,7,8-tetrahydro-8,8-dimethyl-2-naphthalenyl)-2- naphthalenecarboxylic acid 101705-40-2
Retinal 6.11 102586-39-0
4-(Acetylamino)phenylretinoate 103810-85-1
5-Methyl-7-(2,6-dimethyl-6-ethoxycarbonyl-3-oxo-1-cyclohexyl)-2,4,6- heptatrienoic acid 104544-35-6
N-Homocysteine thiolactonyl retinamide 105918-76-1
N-(all-trans-Retinoyl)-DL-leucine 110683-02-8
N-Retinoylleucine 110769-97-6
N-Retinoylglycine 110848-62-9
14-Carboxy-13-cis-retinamide-sepharose 4B 123757-90-4
3'-Azido-3'-deoxythymidine-retinoic acid ester 125780-97-4
16-Hydroxyisotretinoin 126532-33-0
all-trans-Retinylidene methyl nitrone 126924-36-5
Isotretinoin anisatil 127471-94-7
10,20-Methanoretinal 128434-80-0
4-(2-Hydroxyethoxy)retinoic acid 133697-07-1
Tauret 133867-05-7
7-Hydroxymethyl-3,11,15-trimethyl-2,4,6,10,14-hexadecapentaenoic acid 134678-59-4
(14R)-14-Hydroxy-4,14-retro-retinol 139257-77-5
13-cis-12-(3'-Carboxyphenyl)retinoic acid 141948-79-0
Methyl-5,8-epoxyretinoate 147650-80-4
14-Hydroxy-4,14-retro-retinol 153219-51-3
13,14-Dihydroxyretinol 157153-38-3
SALES SPECIFICATION

APPEARANCE

 yellow to light-orange crystalline
ASSAY

99.0% min

WATER

1.0% max

HEAVY METALS

20ppm max
ISOTRETINOIN

1.0% max

LOSS ON DRYING

0.2% max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: