TOPIRAMATE

PRODUCT IDENTIFICATION
CAS NO. 97240-79-4

TOPIRAMATE

EINECS NO.  
FORMULA C12H21NO8S
MOL WT. 339.36

H.S. CODE

 2935.00.6000

TOXICITY

  
SYNONYMS Topamax; Tracrium; Epitomax;
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene- beta-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate;
SMILES

[C@]12([C@H]([C@H]3[C@@H](CO2)OC(O3)(C)C)OC(O1)(C)C)COS (=O)(=O)N

CLASSIFICATION

Anticonvulsant, Antioxidant, Antiepileptic, Anti-Obesity, Neuroprotective

EXTRA NOTES

 Kainate GluR5 receptor antagonist. Hypoglycemic agent

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 122 - 126 C
BOILING POINT 0.91 - 0.93
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 Health: 2, Flammability: 0, Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Topiramate

PubChem Compound Summary - Topiramate

Drug Bank -  Topiramate

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Topiramate

http://www.ebi.ac.uk/ - Topiramate

http://www.ncbi.nlm.nih.gov/ -  Topiramate

Local
Topiramate is a sulfamated monose that interferes with calcium and sodium channels; used as an anticonvulsant in the treatment of some seizures  including jerking of limbs, frothing at the mouth, and loss of consciousness due to a lesion in a specific cerebral cortex. Symptoms vary with different lesion locations. It is a white crystalline powder with a bitter taste; administered orally; soluble in acetone, chloroform, dimethylsulfoxide, ethanol and alkaline solutions; melting point 122 - 126 C. The chemical designation is 2,3:4,5-Bis-O-(1-methylethylidene)- beta-D-fructopyranose sulfamate.

APIs for Treatments of Alcohol Dependence

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97-77-8

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 4205-90-7

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 16590-41-3
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 52485-79-7
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 54910-89-3

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 55096-26-9
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Apraclonidine hydrochloride 73218-79-8
Acamprosate calcium 77337-73-6
Acamprosate 77337-76-9

Topiramate

97240-79-4
Ondansetron hydrochloride dihydrate  99614-01-4
Ondansetron 99614-02-5
Ondansetron hydrochloride 103639-04-9
SALES SPECIFICATION

APPEARANCE

 white crystalline powder
ASSAY

98.0% ~ 101.5%

LOSS ON DRYING

0.5% max

SULFATED ASH

0.1% max

MELTING POINT

 122 - 126 C

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

Irritant

GHS

 
SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338
EC DIRECTIVES

 
HAZARD CODES

RISK PHRASES

36/37/38

SAFETY PHRASES

26-36
PRICE INFORMATION