PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

O([C@@H]1[C@H]([C@H](O[C@H]2O[C@@H]([C@@H](O)C[C @H] 2N)CN) [C@@H](N)C[C@H]1N)O) [C@H]1O[C@@H]([ C@@H ](O)[C@@H]([C@H]1O )N)CO.S(O)( O)(=O)=O

CLASSIFICATION

Antibiotic, Aminoglycoside

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

REFRACTIVE INDEX

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Tobramycin

Google Scholar Search - Tobramycin sulfate

Drug Information Portal (U.S. National Library of Medicine) - Tobramycin sulfate

PubChem Compound Summary - Tobramycin sulfate

Drug Bank -  Tobramycin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Tobramycin sulfate

http://www.ebi.ac.uk/ - Tobramycin

http://www.ncbi.nlm.nih.gov/ - Tobramycin sulfate

http://www.sigmaaldrich.com/
Application:Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance

Local:
Tobramycin, an aminoglycoside antibiotic derived from species of Streptomyces or produced synthetically, inhibits protein synthesis by binding with the 30S ribosomal subunit. Tobramycin is used for the treatment of a wide variety of infections caused by susceptible gram-negative organisms. It is effective against a wide range of aerobic gram-negative bacilli and some gram-positive bacteria but not effective against enterococci. It is used topically in the treatment of external infections of the eye and its adnexa. Chemical designation is O-3-amino-3-deoxy-alpha- D-gluco pyranosyl(1→4)-O-[2,6-diamino- 2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-L-streptamine. The sulfate salt of tobramycin is soluble in water; administered intravenously and intramuscularly.

APPEARANCE

CONTENT

900µm/mg

IDENTIFICATION

Complies

pH

9 - 11

RESIDUE ON IGNITION

1.0% max

WATER

8.0% max

APPEARANCE

CONTENT

635 - 740µm/mg

IDENTIFICATION

Complies

pH

6 - 8

WATER

2.0% max

RESIDUE ON IGNITION

1.0% max

2 eu/mg max

HEAVY METALS

20ppm max

HAZARD OVERVIEW

Target Organ Effect:Target Organs. Aminoglycosides are associated with significant nephrotoxicity and/or ototoxicity., ears, Kidney. Harmful in contact with skin or if inhaled. May damage fertility or the unborn child.

GHS

Danger

PICTOGRAMS

HAZARD STATEMENTS

H312-H332-H360

P STATEMENTS

P201-P280-P308 + P313

T:Toxic

RIS PHRASES

61-20/21/22

SAFETY PHRASES

53-22-36/37/39-45