TAMOXIFEN CITRATE

PRODUCT IDENTIFICATION

CAS NO. 10540-29-1 (Base)
54965-24-1 (Citrate)

TAMOXIFEN

EINECS NO. 234-118-0, 259-415-2
FORMULA C26H29NO·C6H8O7
MOL WT. 563.65

H.S. CODE

 

TOXICITY

 
SYNONYMS Genox; Kessar; Nolvadex;
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-hydroxy-1,2,3- propanetricarboxylate (1:1);  (Z)-[2-[4-(1,2-diphenylbut-1-enyl) phenoxy]ethyl] dimethylammonium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate; trans-1-(p-beta-Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate; (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine citrate;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT 143 - 146 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Tamoxifen and its metabolite 4-hydroxytamoxifen are nonsteroidal selective estrogen receptor modulators (SERMs) which mimic the action of estrogen in cardiovascular system and skeletal system. It blocks estradiol-stimulated VEGF production in breast tumor and acts as an anti-estrogen and antineoplastic in breast tissue; used in the palliative treatment of breast cancer in postmenopausal women and to stimulate ovulation in infertility. The chemical designation of tamoxifen is (Z)-2-[4-(1,2-diphenyl-1-butenyl) phenoxy]-N,N- dimethylethanamine. The trans form is active. The citrate salt of tamoxifen is a white to off-white crystalline powder; insoluble in water; freely soluble in glacial acetic acid; slightly sobuble in alcohol, acetone; oral antiestrogen.

SALES SPECIFICATION

APPEARANCE

fine off-white crystalline powder

IDENTIFICATION

Complies Test A,B

PURITY

99.0% min (trans-Form 99.0% min + cis-Form 1.0% max)

MELTING POINT

143 - 146 C

RELATED SUBSTANCE

1.0% max

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.2% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 45-60-61-22-64, Safety Phrases: 53-36/37/39-45