SUMATRIPTAN

PRODUCT IDENTIFICATION
CAS NO. 103628-46-2

SUMATRIPTAN

EINECS NO.  
FORMULA C13H19N3O2S
MOL WT. 281.37

H.S. CODE

  

TOXICITY

  
SYNONYMS Imigran; Imitrex;
3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to off-white crystalline powder
MELTING POINT 164 - 165 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

APPLICATIONS
Sumatriptan [su(lfon)am(ide) triptan] is a selective serotonin antagonist used in the treatment of migraine headache. It is a white to off-white powder; soluble in water and in saline. Its chemical designation is 3-[2-(Dimethylamino)ethyl]- N-methyl- indole- 5-methanesulfonamide. Its succinate is administered subcutaneously and orally.
SALES SPECIFICATION

APPEARANCE

 White to off-white crystalline powder

IDENTIFICATION

Complies

ASSAY (HPLC)

 98.5% min
MELTING POINT 164 - 165 C

LOSS ON DRYING

0.5% max
HEAVY METALS

20ppm max

RESIDUE ON IGNITION

0.1% max
RELATED MATERIAL 1.5% max
TRANSPORTATION
PACKING

10kgs in tin can

HAZARD CLASS  
UN NO.  

GENERAL DESCRIPTION OF TYRAMINE & TRYPTAMINE

Tyramine [4-(2-Aminoethyl)phenol] is a monoamine compound of 4-hydroxy phenethylamine. It is derived from tyrosine, an amino acid (protein building block) that is the precursor of norepinephrine. It, through its effect on neurotransmitters, may affect several health conditions, including Parkinson's disease, depression, alcohol withdrawal support, and Phenylketonuria. (PKU). Tyramine is naturally found in plant and animal tissues, certain cheeses and ergot or produced synthetically. It is metabolized by monoamine oxidase. Tyramine or its derivatives can be used in pharmaceutical industry such as:

  • Sympathomimetic or adrenergic drugs themselves or intermediate of them.
  • Intermediate for bezafibrate used in the treatment of high cholesterol levels.
  • Determination of peroxide activity in the fluorescence enzyme immunoassay for insulin.
  • False transmitter.

Tryptamine [3-(2-Aminoethyl)indole] is a biologically important monoamine compound derived  by the decarboxylation of tryptophan, indole side chain amino acid. In addition to its function to build the structure of protein, tryptophan is a precursor for neurotransmitter and neurohormone. Tryptamine (biological monoamine) effects vasoconstriction by causing the release of norepinephrine at postganglionic nerve endings. Several mental disorders and health conditions are explained as due to either an excess or deficiency of monoamines. There are many natural tryptamines in both animal and plant as well as synthetics modified by chemical constituents and substituted at appropriate positions in the motif. Common tryptamine class compounds include;

  • Bufotenine (CAS #: 487-93-4): (5-Hydroxy-N,N-dimethyltryptamine, pressor agent, epinephrine-like.
  • DMT (CAS #: 61-50-7): N,N-Dimethyltryptamine, a psychedelic and hallucinogenic.
  • Luzindole (CAS #: 117946-91-5): N-Acetyl-2-benzyltryptamine
  • Melatonin (CAS #: 73-31-4, 8041-44-9): N-Acetyl-5-methoxytryptamine, biological clock hormone.
  • Psilocin: 4-Hydroxy-N,N-dimethyltryptamine.
  • Psilocybin (CAS #: 520-52-5): 4-Phosphoryloxy-N,N-dimethyltryptamine, a hallucinogenic.
  • Serotonin (CAS #: 50-67-9): 5-Hydroxytryptamine, a vasoconstrictor.
  • Sumatriptan( CAS #: 103628-46-2) 4-Hethylaminosulfonyl-N,N-dimethyltryptamine, selective serotonin antagonist used in the treatment of migraine headache.