PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
REFRACTIVE INDEX
APPLICATIONS
Sulfonamide is an organic sulfur compounds containing the radical -SO2NH2 (the amides of sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering with the metabolic processes in bacteria that require PABA. They act as antimicrobial agents by inhibiting bacterial growth and activity and called sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug includes;
- Topical sulfonamides: sulfacetamide; silver sulfadiazine; mafenide;
- Rapidly absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole;
- Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole; sulfasalazine; sulfaguanidine;
- Long lasting sulfonamides: sulfadoxine;
- Others: sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole;
Sulfasalazine, a sulfonamide derivative, is used as an antimicrobial agent by inhibiting bacterial growth and activity mainly in the treatment of ulcerative colitis and in the treatment of rheumatoid arthritis, administered orally. It is a yellow to brown powder; insoluble in water; decomposes at melting point 240 C.
APPEARANCE
IDENTIFICATION
Complies
ASSAY
LOSS ON DRYING
1.0% max
RESIDUE ON IGNITION
0.5% max
CHLORIDE
0.015% max
SULFATE
0.5% max
HEAVY METALS
20ppm max
OTHER INFORMATION