| CAS
NO. |
3810-74-0 |
|
| EINECS NO. |
223-286-0 |
| FORMULA |
(C21H39N7O12)2
(H2SO4)3 |
| MOL
WT. |
1457.39 |
|
H.S.
CODE
|
3004.10 |
|
TOXICITY
|
Oral rat LD50:
430 mg/kg |
| SMILES |
|
| SYNONYMS |
Streptomycin A Sulfate;
|
| Streptomycin sulfate (2:3) salt; Streptomycin sesquisulfate; Strycin;
Streptobrettin; Vetstrep; Agrimycin 17; phytomycin; strepcin; |
| Sstrepuet;
D-Streptamine,O-2-deoxy-2-(methylamino)-ес-L-glucopyransyl-(1-2)-O-5-
deoxy-3-c-formyl-ес-L-luxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-sulfate
(2:3)(salt), (4S,4aR,5S,5aR,6S,12aS)- 4-dimethylamino-1,4,4a,5,5a,6,11,
12a-octahydro- 3,5,6,10,12,12a- hexahydroxy-6-methyl,1,11-
dioxanaphthacene-
2-carboxamide; |
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to off-white
powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Soluble |
| pH |
4.5
- 7.0 (20% sol.) |
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
APPLICATIONS
|
Streptomycin is a Water-soluble antibiotic drug that is principally used for the
treatment of tuberculosis in conjunction with other drugs like isonicotinic acid
hydrazide (isoniazid). Aminoglycoside is any of a group of antibiotics derived from various species of
Streptomyces or Micromonosporaceae, while some of which are produced
synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S
ribosomal subunit and in some cases the 50S subunit, causing miscoding and thus
inhibiting initiation and
elongation during protein synthesis. They include;
- Amikacin
- Gentamicin
- Kanamycin
- Neomycin
- Netilmicin
- Paromomycin
- Streptomycin
- Tobramycin
Streptomycin is the first isolated aminoglycoside antibiotic derived from
Streptomyces griseus. It is effective against a wide variety of aerobic
gram-negative bacilli and some gram-positive bacteria, including mycobacteria.
But Its use is limited because of the emergence of resistant strains.
|
| SALES
SPECIFICATION |
|
ORAL GRADE |
|
APPEARANCE
|
white to off-white
powder |
|
ASSAY |
720 I.U/mg |
|
IDENTIFICATION
|
pass
(A,B,C,D,E)
|
|
SULFATE
|
18.0
- 21.5% |
|
STREPTOMYCIN B |
3.0%
max
|
|
pH
|
4.5
- 7.0 (20% sol.) |
|
CLARITY
OF SOLUTION
|
pass
|
|
LOSS
ON DRYING
|
7.0%
max
|
|
ASH
|
1.0%
max
|
|
INJECTION GRADE |
|
APPEARANCE
|
white to off-white
powder |
|
ASSAY |
720
I.U/mg |
|
IDENTIFICATION
|
pass
(A,B,C,D,E)
|
|
SULFATE
|
18.0
- 21.5% |
|
STREPTOMYCIN B |
3.0%
max
|
|
pH
|
4.5
- 7.0 (20% sol.) |
|
CLARITY
OF SOLUTION
|
pass
|
|
LOSS
ON DRYING
|
7.0%
max
|
|
ASH
|
1.0%
max
|
|
PYROGENS |
pass
|
|
STERILITY |
pass
|
|
FEED
GRADE
|
|
APPEARANCE
|
white to off-white
powder |
|
IDENTIFICATION
|
720
I.U/mg |
|
CLARITY
OF SOLUTION
|
90.0%
min
|
|
MeOH
|
0.3%
max
|
|
pH
|
4.5
- 7.0 (20% sol.) |
|
STREPTOMYCIN B |
3.0%
max
|
|
LOSS
ON DRYING
|
7.0%
max
|
|
SULFATE
|
18.0
- 21.5% |
|
SULFATED
ASH
|
1.0%
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
Hazard Symbols: n/a, Risk Phrases: n/a, Safety
Phrases: 24/25
Shelf Life: 4 years |
|
PRICE INFORMATION |
|
|