SODIUM SALICYLATE

PRODUCT IDENTIFICATION
CAS NO. 54-21-7

SODIUM SALICYLATE
EINECS NO.

200-198-0
FORMULA HOC6H4COONa
MOL WT. 160.11

H.S. CODE

 2918.21

TOXICITY

 Oral rat LD50: 930 mg/kg
SYNONYMS 2-Hydroxy Benzoic acid, monosodium salt;
Diuratin; o-hydroxybenzoic acid, sodium salt; Salicylic acid, sodium salt;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystals
MELTING POINT 200 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 110 (g/l)
pH 5 - 6
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 1 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION AND APPLICATIONS
Salicylic Acid is a white crystalline powder or needle-shaped crystals with sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water; melts at 158°C. The sodium salt form (sodium salicylate) is common commercially, prepared from mainly sodium phenolate with carbon dioxide under heating and pressure. It contains both a hydroxyl and a carboxyl group, which react with either an acid or an alcohol. The carboxyl group forms esters with alcohols; e.g. methyl salicylate is formed with methanol, which used in food flavorings and preservatives; menthyl salicylate is formed with methanol, which is used in suntan lotions. The hydroxyl group reacts with acetic acid to form acetylsalicylic acid (called aspirin) which is the most widely common antiseptic and antipyretic agent. Phenyl salicylate (called salol) is formed with phenol, which is also used as an antiseptic and antipyretic agent. The sodium salt (Sodium salicylate), a shiny white powder, is used for antiseptics preparations and as a preservative. In addition to its analgesic and antipyretic properties, salicylic acid possesses keratinolytic properties and fungicidal properties. It ans its derivatives are used in the treatment of hyperkeratotic, dandruff, ichthyosis and psoriasis as well as in the treatment of fungal skin infections such as tinea. Para-Aminosalicylic acid (abbreviated PAS and PASA) is an analogue of para-aminobenzoic acid (abbreviated PABA) that inhibits folic acid synthesis in Mycobacterium tuberculosis and is bacteriostatic, inhibits growth and multiplication of the tubercle bacillus. Para-Aminosalicylic acid and its sodium salt (sodium p-Aminosalicylate) are bacteriostatic against mycobacteria and used in the treatment of tuberculosis; administered orally. Brand names are Tubasal, Nemasol Sodium and etc. Aminosalicylic acids are pharmaceutically active ingredients including anti-infectives against colds, flu, or other virus infections. Mesalamine (5-aminosalicylic acid, abbreviated 5-ASA) an active metabolite of sulfasalazine, used to treat inflammation of the rectum and lower colon, mild to moderate ulcerative colitis proctosigmoiditis, and proctitis. Para-Aminosalicylic acid (4-hydroxybenzoic acid) is used as an intermediate of bacteriostatic agent specially for parabens (alkyl esters of p-hydroxy benzoic acid) which used in food and personal care products as a preservative. It is applied in the production of liquid crystal polymers. It is also used as an intermediate of dyes, insecticides, pharmaceutical, pesticides and other chemical compounds. Salicylic Acid and its derivatives are important for the preparation of other pharmaceutical products, dyes, flavours, and preservatives.
SALES SPECIFICATION
BP 98 / USP 24

APPEARANCE

 white crystals
ASSAY

99.0 - 101.0%

ACIDITY

Conform to BP, USP Standard

CLARITY

Conform to BP, USP Standard

HEAVY METALS

20ppm max

CHLORIDE

200ppm max

LOSS ON DRYING

0.5% max
SULFATE

600ppm max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-36/37/39