RISPERIDONE

RISPERIDONE
PRODUCT IDENTIFICATION
CAS NO.	106266-06-2
EINECS NO.
FORMULA	C₂₃H₂₇FN₄O₂
MOL WT.	410.49
H.S. CODE	2934.99.3000
TOXICITY	Oral Rat LD50: 56600ug/kg
SYNONYMS	Risperidal; Risperidone;
3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl)ethyl)-6,7,8,9-tetrahydro-2- methyl-4H-pyrido [1,2-a] pyrimidin-4-one; Apexidone; Risperidona; Risperidonum; Sequinan;
SMILES	c1(c2c(cc(F)cc2)on1)C1CCN(CCc2c(n3c(CCCC3)nc2C)=O)CC1
CLASSIFICATION	Psychotropic, Tranquilizing agent, Atypical antipsychotic, Dopamine antagonist, Serotonin antagonistBenzisoxazole, Piperidine, Lactam
EXTRA NOTES	Risperidone is an antipsychotic; serotonin-dopamine antagonist. A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	White powder
MELTING POINT	170 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Insoluble
pH
VAPOR DENSITY
log P	3.49 (Octanol-water)
OH RATE CONSTANT	1.53E-10 (cm3/molecule-sec at 25 C Atmospheric)
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Risperidone PubChem Compound Summary - Risperidone http://www.ncbi.nlm.nih.gov/ Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding http://www.bcc-asa.org/ Risperidone Treatment of Autistic Disorder: Longer-Term Benefits and Blinded Discontinuation After 6 Months http://www.choiceandmedication.org/ What is risperidone?:Risperidone (sometimes also known by its trade name Risperdal®) is usually used to help treat the symptoms of psychosis, schizophrenia and mania, and to prevent these symptoms coming back. It is often also used to help the symptoms of ADHD and bipolar mood disorder. It is one of a group of medicines called antipsychotics or neuroleptics. It is made as tablets, melt-in-the-mouth tablets, a syrup and a long-acting injection. Local: Antihistamine is a group of drugs characterized by the ability to block the action of histamines on H1 receptors. The principal use is to treat allergies, hives, and other local and systemic hypersensitivity reactions. Some antihistamines can also be used in the control of insomnia, motion sickness, or vertigo. First-generation antihistamines can cause side effect of sedation. Second-generation antihistamines (fexofenadine, loratadine) are nonsedating. Risperidone, a benzisoxazole derivative compound, is used as an antipsychotic agent for the therapy in schizophrenia and other related psychotic disorders. It is a white to off-white powder; insoluble in water, soluble in methylene chloride, methanol and dilute acid. Its chemical designation is 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl)ethyl)-6,7,8,9-tetrahydro-2- methyl-4H-pyrido [1,2-a] pyrimidin-4-one.
SALES SPECIFICATION
APPEARANCE	White to off-white powder
IDENTIFICATION	Complies ( IR spectrum)
ASSAY (HPLC)	98.5 - 101.0%
SOLUTION CLARITY	clear and colorless
LOSS ON DRYING	0.5% max
HEAVY METALS	20ppm max
SOLVENT RESIDUE	0.5% max
SULFATED ASH	0.1% max
TRANSPORTATION
PACKING
HAZARD CLASS	6.1 (Packing group: III)
UN NO.	2811
GENERAL DESCRIPTION OF ANTIPSYCHOTIC AGENTS
The term antipsychotic refers to a group of drugs effective in the treatment of psychosis including schizophrenic, paranoid, schizoaffective, bipolar disorder, and other psychotic disorders. Traditional antipsychotic agents have phenothiazine structure chemically. Phenothiazinene drugs are adrenergic blocking agents. Their pharmacologic actions including central nervous system depression, prolongation and potentiation of the effects of narcotic and hypnotic drugs, hypotensive activity, and antispasmodic, antihistaminic, and antiemetic activity. Other chemcial structures for antipsychotic drugs are diverse, they include thioxanthene, butyrophenone, dibenzoxazepine, dihydroindolone, benzisoxazole, and diphenylbutylpiperidine. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, a-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is known to be responsible for their major effects such as not only antipsychotic action by blockade in the mesolimbic and mesocortical areas and and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla but also extrapyramidal side effects (dystonia, akathisia, parkinsonism, and tardive dyskinesia) by blockade in the basal ganglia and sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion, and constipation) by blockade of histamine, cholinergic, and adrenergic receptors. The antipsychotic agents may be divided by chemical group and and the decreased propensity of extrapyramidal side effects into two main groups and a new class which is being processed. Typical Antipsychotic Chlorpromazine (CAS #: 50-53-3, Phenothiazine with aliphatic side chain) Promazine (CAS #: 58-40-2, Phenothiazine with aliphatic side chain) Triflupromazine (CAS #: 146-54-3, Phenothiazine with aliphatic side chain) Methotrimeprazine (CAS #: 60-99-1, Phenothiazine with aliphatic side chain) Thioridazine (CAS #: 50-52-2, Phenothiazine with piperidine side chain) Mesoridazine (CAS #: 5588-33-0, Phenothiazine with piperidine side chain) Acetophenazine (CAS #:2751-68-0, Phenothiazine with piperazine side chain) Perphenazine (CAS #: 58-39-9, Phenothiazine with piperazine side chain) Trifluoperazine (CAS #: 117-89-5, Phenothiazine with piperazine side chain) Fluphenazine (CAS #: 69-23-8, Phenothiazine with piperazine side chain) Prochlorperazine (CAS #: 58-38-8, Phenothiazine with piperazine side chain) Chlorprothixene (CAS #: 113-59-7 Thioxanthene) Thiothixene (CAS #: 22189-31-7, Thioxanthene) Haloperidol (CAS #: 52-86-8, Phenylbutylpiperadine) Pimozide (CAS #: 2062-78-4, Phenylbutylpiperadine) Loxapine (CAS #: 1977-10-2, Dibenzoxazepine) Molindone (CAS #: 7416-34-4, Dihydroindolone) Atypical Antipsychotics Clozapine (CAS #: 5786-21-0, Dibenzoxazepine) Olanzapine (CAS #: 132539-06-1, Dibenzoxazepine) Quetiapine (CAS #: 111974-69-7, Dibenzoxazepine) Ziprasidone (CAS #: 138982-67-9, Benzisoxazole) Risperidone (CAS #: 106266-06-2, Benzisoxazole) Partial dopamine agonists Aripiprazole (CAS #: 129722-12-9, Dihydroquinolinone) Lithium carbonate
SAFETY INFORMATION
GHS	OSHA Hazards: Toxic by ingestion
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H301 Toxic if swallowed.
PRECAUTIONARY STATEMENTS	P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
EC DIRECTIVES
HAZARD CODES	T Toxic
RISK PHRASES	25 Toxic if swallowed
SAFETY PHRASES	28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 36 Wear suitable protective clothing 45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
PRICE INFORMATION