PRODUCT IDENTIFICATION

110-85-0

H.S. CODE

TOXICITY

Diethylenediamine; Diethyleneimine; Dispermine;

Antiren; Hexahydropyrazine; Piperazidine; Pipersol; Pyrazine hexahydride; Uvilon; 1,4-Diazacyclohexane; 1,4-Piperazine; 1,4-Diethylenediamine; Piperazin (German); N,N-Diethylenediamine; Hexahydro-1,4-diazine; Piperazidine; Pyrazine hexahydrate; Piperazin (German); Piperazina (Spanish); Pipérazine (French); Other RN: 8017-90-1, 8027-81-4, 81546-15-8, 854880-15-2, 861800-35-3

C1CNCCN1

CLASSIFICATION

Piperazine, Anthelmintic

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

White flake Ammonia like odor

1.1

3.0

340 C

REFRACTIVE INDEX

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Material Safety Data Sheet

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Piperazine

http://www.chemistrydaily.com/
Piperazine is a six-sided organic ring compound containing two opposing nitrogen atoms (see image). The piperazines are a broad class of chemical compounds, all of which contain a piperazine functional group. Piperazines were originally named because of their chemical similarity with piperidine, a constiuent of piperine in the black pepper plant (Piper nigrum). This has led to the erroneous belief that piperazines are naturally derived from black pepper. In reality, no piperazines occur naturally; they are usually artificially synthesized by reacting alcoholic ammonia with 1,2-dichloroethane. Many piperazines are successful drugs. Notable piperazine drugs include:
BZP (recreational drug)
Dramamine (motion sickness drug)
Viagra (impotence drug)
A large number of piperazine compounds have anthelmintic (anti-parasitic) action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines. These drugs are often referred to simply as "piperazine" which may cause confusion between the specific anthelmintic drugs and the entire class of piperazine-containing compounds. Piperazines are also used in the manufacture of plastics, resins, pesticides, and other industrial materials.

Local:
Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and  poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a main moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine  has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants.

White flake

PURITY

99.5% min

WATER

INDIVIDUAL IMPURITY

0.5% max

GHS

PICTOGRAMS

HAZARD STATEMENTS

H314:  Causes severe skin burns and eye damage
H317:  May cause an allergic skin reaction
H334:  May cause allergy or asthma symptoms or breathing difficulties if inhaled
H361fd:  Suspected of damaging fertility. Suspected of damaging the unborn child
H228:  Flammable solid

PRECAUTIONARY STATEMENTS

P301 + P330 + P331:  IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P305 + P351 + P338:  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P261:  Avoid breathing dust/fume/gas/mist/vapors/spray
P304 + P341:  IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing
P342 + P311:  If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician
P280:  Wear eye protection/face protection
P273:  Avoid release to the environment

F Highly flammable
C Corrosive
XN Harmful

RISK PHRASES

11:  Highly flammable.
34:  Causes burns.
42/43:  May cause sensitisation by inhalation and skin contact.
62:  Possible risk of impaired fertility.
63:  Possible risk of harm to the unborn child.

SAFETY PHRASES