PENICILLIN G SODIUM

PRODUCT IDENTIFICATION

CAS NO. 69-57-8

PENICILLIN G SODIUM

EINECS NO. 200-710-2
FORMULA C16H17NaN2O4S
MOL WT. 356.37

H.S. CODE

2941.10.2000

TOXICITY

Oral rat LD50: 8900 mg/kg
SYNONYMS Benzylpenicillin Sodium; Benzylpenicillinic acid Sodium salt;
Monosodium 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1- azabicyclo (3.2.0) heptane-2-carboxylate; Sodium penicillin G; 4-Thia-1-azabicyclo(3,2,0) heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6 -(2-phenylacetamido)-, monosodium salt; Sodium benzylpenicillinate; Sodium [2S-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)- 4-thia-1-azabicyclo [3.2.0]heptane-2-carboxylate;

SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)Cc3ccccc3) C(=O)[O-]) C.[Na+]

CLASSIFICATION

Antibiotic, Antibacterial

EXTRA NOTES

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission. [MeSH]
Other RN: 1406-09-3, 8049-60-3, 61-33-6 (parent)

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 209 - 212 C (Decpmposes)
BOILING POINT  
SPECIFIC GRAVITY 1.41
SOLUBILITY IN WATER Soluble
pH 5.5 - 7.5 (3% soln)
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS Health: 3; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Penicillin G sodium

Wikipedia Linking - Penicillin G sodium

Google Scholar Search - Penicillin G sodium

U.S. National Library of Medicine - Penicillin G sodium

PubChem Compound Summary - Penicillin G sodium

Drug Bank -  Penicillin G sodium

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Penicillin G sodium

ChEBI (http://www.ebi.ac.uk/chebi/) -  Penicillin G sodium

NCBI (http://www.ncbi.nlm.nih.gov/) -  Penicillin G sodium

EPA - Substance Registry Services - Penicillin G sodium

Local:
· Penicillin: Any of a large group of broad-spectrum antibiotic drugs derived directly or indirectly from molds of the genus Penicillium and other soil-inhabiting fungi grown on special culture media, which exert a bacteriocidal as well as a bacteriostatic effect on susceptible bacteria during their growth stage by the inhibition of biosynthesis of their cell wall mucopeptide. Penicillin, beta-lactam antibiotics, possess a four-ring beta-lactam structure shares a nitrogen and a carbon atom with fused a five-membered thiazolidine ring. These antibiotics have low toxicity for the host but effective against most gram-positive bacteria including pathogens (streptococci, staphylococci, pneumococci); clostridia; some gram-negative gonococci; some spirochetes (Treponema pallidum and T. pertenue); and some fungi. Certain strains of some target species, e.g., staphylococci, secrete the enzyme penicillinase, which inactivates penicillin and confers resistance to the antibiotic.

· Penicillic acid [CAS RN: 90-65-3]: an antibiotic substance produced by several species of Penicillium and Aspergillus; a white solid soluble in water; melting point 83 - 84 C; antibiotic and mycotoxin induceing DNA single-strand breaks, toxic to animal tissues also, causing nephrotoxicity and other damage.

· Penicillin G [also called benzylpenicillin, CAS RN: 61-33-6]: the first and the most widely used penicillin compound for medicinal use. It is used in the form of its stable salts (benzathine, potassium, procaine, and sodium) to treat principally the infections due to penicillin-susceptible gram-positive bacteria, gram-negative cocci, Treponema pallidum, and Actinomyces israelii.

· Penicillin G Benzathine [CAS RN: 41372-02-5]: the benzathine salt of penicillin G; having a long-sustained action, administered orally, intramuscularly. Chemically designation is (2S,5R,6R)- 3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid with N,N' -Dibenzylethylenediamine (2:1). It is a white crystalline powder; slightly soluble in water and sparingly soluble in alcohol.

· Penicillin G Potassium [CAS RN: 113-98-4]: the potassium salt of penicillin G; administered orally and by intravenously. It is a white crystalline powder; odorless, moderately hygroscopic; soluble in water.

· Penicillin G Procaine [CAS RN: 6130-64-9]: the procaine salt of penicillin G; having a long-sustained action, administered intramuscularly. Chemically designation is (2S,5R,6R)- 3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid with 2-(Diethylamino)ethyl p-aminobenzoate (1:1). It is a white crystalline powder; slightly soluble in water.

· Penicillin G sodium [CAS RN: 69-57-8]: the sodium salt of penicillin G having a potency of 1500–1750 U per mg; administered intramuscularly and intravenously.

· Penicillin N (also called adicillin, CAS RN: 525-94-0]: a cephalosporin that is more active against gram-negative organisms than penicillin G and is highly active against Neisseria; has been used in the treatment of typhoid fever and gonorrhea.

· Penicillin O: similar to penicillin G in antibiotic action but produced by adding a precursor to the culture medium; penicillin O and its potassium and sodium salts are hypoallergenic.

· Penicillin V: [CAS RN: 87-08-1] a semisynthetic penicillin prepared from cultures of the mold Penicillium in the presence of 2-phenoxyethanol with an autolysate of yeast as the source of nitrogen; a white, crystalline powder, soluble in alcohol and acetone; resists destruction by high humidity (gastric juice), thus orally effective.

· Penicillin V Benzathine [CAS RN: 63690-57-3] : the benzathine salt of penicillin V, administered orally. Chemical designation is [2S-(2a,5a,6b)]-3,3 -dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4- thia-1- azabicyclo[3.2.0] heptane-2-carboxylic acid with N,N' -Dibenzylethylenediamine (2:1).

· Penicillin V Potassium [CAS RN: 132-98-9]: the potassium salt of penicillin V, administered orally. Chemical designation is [2S-(2a,5a,6b)]-3,3 -dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4- thia-1- azabicyclo[3.2.0] heptane-2-carboxylic acid, monopotassium salt.

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

pass

CONTENT (HPLC)

96.0 - 101.0%

POTENCY

1550 min (units/mg)

OPTICAL ROTATION +285° - +310°

WATER (K.F)

1.0% max

COLOR

60max (3g/10 ml water; 425 nm)

ABSORBANCE 0.1 max (280 nm), 0.1max (325 nm)
STERILITY

Non

TRANSPORTATION
PACKING  
HAZARD CLASS Not regulated
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Skin irritation. Eye irritation. Hazard statements: May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

GHS

 

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H317-H334

P STATEMENTS

P310

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

42/43

SAFETY PHRASES

22-36/37-45

PRICE INFORMATION