OMEPRAZOLE SODIUM

OMEPRAZOLE SODIUM
PRODUCT IDENTIFICATION
CAS NO.	73590-58-6, (Base) 95510-70-6 (Sodium)
EINECS NO.
FORMULA	C₁₇H₁₈N₃O₃S·Na
MOL WT.	366.82
H.S. CODE
TOXICITY
SYNONYMS	Losev; Omeprazole; Prilosec;
(R,S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]- 1H-benzimidazole monosodium salt; Losec Sodium; Omepral; Andra; Sodium 5-methoxy-2-[(4-methoxy-3,5- dimethyl-pyridin-2-yl)methylsulfinyl]benzoimidazole;
SMILES
CLASSIFICATION	PROTON PUMP INHIBITORS /
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
APPLICATIONS
Proton Pump Inhibitors (PPIs) are a group of drugs to reduce the production of acid by blocking the enzyme (hydrogen-potassium adenosine triphosphatase) in parietal cells that produces acid. They are used in the treatment of ulcers caused by taking nonsteroidal anti-inflammatory drugs, Zollinger-Ellison syndrome, and symptomatic gastroesophageal reflux disease. They are also used in eradicating Helicobacter pylori, in combination with antibiotics (e.g. amoxycillin, clarithromycin or metronidazole in case of penicillin-hypersensitive patients). Another lowering-acid medicines are H2 antagonist drugs which reduce the production of acid by blocking the H2 subtype of histamine receptors. Commecially available PPIs include; Omeprazole (CAS RN: 73590-58-6) Lansoprazole (CAS RN: 103577-45-3) Esomeprazole (CAS RN: 161796-78-7) Pantoprazole (CAS RN: 102625-70-7) Rabeprazole (CAS RN: 117976-89-3) Omeprazole, a substituted benzimidazole, is a PPI used in the treatment of symptomatic gastroesophageal reflux disease and in combination with clarithromycin duodenal ulcer associated with Helicobacter pylori infection. It is a white to off-white crystalline powder; melts or decomposes at 155 C; very slightly soluble in water; slightly soluble in acetone, isopropanol; freely soluble in ethanol and methanol; administered orally. It is a weak base; unstable under acid conditions, but stable in alkaline media. The chemical designation is (R,S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]- 1H-benzimidazole.
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
IDENTIFICATION	Complies Test A,B,C
ASSAY (HPLC)	98.5 - 101.5%
pH	10.3 - 11.3 (0.02mg/ml solution)
SOLVENT RESIDUE	0.01% max
SULFATED ASH	0.1% max
HEAVY METALS	20ppm max
LOSS ON DRYING	0.1% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases:` 20/21/22,`Safety Phrases:`36
PRICES