NICLOSAMIDE

PRODUCT IDENTIFICATION

CAS NO. 50-65-7

NICLOSAMIDE

EINECS NO. 200-056-8
FORMULA C13H8Cl2N2O4
MOL WT. 327.12

H.S. CODE

 

TOXICITY

 
SYNONYMS  
2',5-dichloro-4'-nitrosalicylanilide; 2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; 5-Chloro-N-(2-chloro-4-nitrophenyl)salicylamide; Bayluscid; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy Benzamide; Dichlosale; Cestocid; Devermine;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish odourless crystalline powder
MELTING POINT 224 - 229 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Niclosamide is a chlorinated salicylanilide pesticide principally used against aquatic vertebrates and crustaceans.It is an anthelmintic effective in the treatment of diphyllobothriasis, diphyllobothriasis, hymenolepiasis. It is used to treat broad tapeworms (or fish, dwarf and beef). Niclosamide is a white to yellowish odourless crystalline powder; melting point 224 C; not soluble in water; sparingly soluble in ether, ethanol, chloroform, and soluble in acetone; administered orally to humans, cats, and dogs. The commercially available ethanolamine salt issolves in distilled water.

Anthelmintic (also spelled  anthelminthic) is a chemical substance used to expel or destroy tapeworms in domestic animals. Some common anthelmintic active ingredients classified by chemical structure include;

  • Benzimidazoles
    • Albendazole (CAS #: 54965-21-8)
    • Fenbendazole (CAS #: 43210-67-9)
    • Mebendazole (CAS #: 31431-39-7)
    • Oxfendazole (CAS #: 53716-50-0)
    • Oxibendazole ((CAS #: 20559-55-1)
    • Triclabendazole (CAS #: 68786-66-3)
  • Diphenylsulfides
    • Bithionol (CAS #:97-18-7)
    • Febantel (CAS #: 58306-30-2)
  • Hexahydropyrazines
    • Diethylcarbamazine (CAS #: 90-89-1)
    • Piperazine (CAS #: 110-85-0)
    • Praziquantel (CAS #: 55268-74-1)
  • Imidazothiazoles
    • Levamisole (CAS #: 14769-73-4)
    • Tetramisol (CAS #: 5036-02-2)
  • Macrocylic Lactones
    • Abamectin (CAS #: 71751-41-2)
    • Doramectin (CAS #: 117704-25-3)
    • Eprinomectin (CAS #: 123997-26-2)
      • Eprinomectin B1a (CAS#: 133305-88-1)
      • Eprinomectin B1b (CAS #: 133305-89-2)
    • Ivermectin (CAS #: 70288-86-7)
      • Ivermectin B1a (CAS #: 70161-11-4)
      • Ivermectin B1b (CAS #: 70209-81-3)
    • Moxidectin (CAS #: 113507-06-5)
  • Salicylanilide
    • Closantel (CAS #: 57808-65-8)
    • Niclosamide Base (CAS #: 50-65-7)
      • Niclosamide Monohydrate (CAS #: 7336-56-2)
      • Niclosamide Ethanolamine salt (CAS #: 1420-04-8)
      • Niclosamide Piperazine salt (CAS #: 34892-17-6)
    • Oxyclozanide (CAS #: 2277-92-1)
    • Rafoxanide  (CAS #: 22662-39-1)
  • Tetrahydropyrimidines
    • Morantel (CAS #: 20574-50-9)
    • Pytrantel Pamoate (CAS #: 22204-24-6)
  • Others
    • Clorsulon (CAS #: 60200-06-8)
    • Nitroxinil (CAS #: 1689-89-0)
SALES SPECIFICATION (as per B.P STANDARD)

NICLOSAMIDE BASE

APPEARANCE

white to yellowish odourless crystalline powder

IDENTIFICATION

Complies Test A, B

ASSAY

98.0 - 102.0%

CHLORIDE

0.05% max

RELATED SUBSTANCES

0.1% max

WATER

0.5% max

SULFATED ASH

0.1% max

NICLOSAMIDE PIPERAZINE SALT

ASSAY

98.0 - 102.0%

PIPERAZINE

10.0 - 13.0%

NICLOSAMIDE ETHANOLAMINE SALT

ASSAY

50.0% min, 70.0% min, 83.0% min, 94.0% min

NICLOSAMIDE

42.0% min, 59.0% min, 70.0% min

TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 61-36/37/38, Safety Phrases: 53-26-37/39-45

GENERAL DESCRIPTION  OF SALICYLANILIDE

Salicylic Acid is a white crystalline powder or needle-shaped crystals with sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water; melts at 158 C. It is prepared commercially by sodium salicylate which derived from sodium phenolate with carbon dioxide under heating and pressure. It contains both a hydroxyl and a carboxyl group, which react with either an acid or an alcohol. The carboxyl group forms esters with alcohols; e.g. methyl salicylate is formed with methanol, which used in food flavorings and preservatives; menthyl salicylate is formed with methanol, which is used in suntan lotions; phenyl salicylate (called salol) is formed with phenol, which is used as an antiseptic and antipyretic agent. The hydroxyl group reacts with acetic acid to form acetylsalicylic acid (called aspirin). Salicylic Acid is important for the preparation of other pharmaceutical products, dyes, flavours, and preservatives. The sodium salt (Sodium salicylate), a shiny white powder, is used for antiseptics preparations and as a preservative. Salicylic Acid derivatives are used in formulating flavors, preservatives and UV absorbers for food and cosmetics as well as plastics. They are used in manufacturing pharmaceuticals mainly analgestics and antipyretics for the relief of pain and fever. Anilide is an amide in which one or more hydrogens are replaced by phenyl; having the C6H5NH2-group. Brominated salicylanilides are used as disinfectants with antibacterial and antifungal activities, used mainly in medicated soaps. Bromsalans are examples:
  • Dibromsalan (CAS #: 87-12-7): 4',5-Dibromosalicylanilide
  • Metabromsalan (CAS #: 2577-72-2): 3,5-Dibromosalicylanilide
  • Tribromsalan (CAS #: 87-10-5): 3,4',5-Tribromosalicylanilide

Some salicylanilide derivatives are used as aromatic amide pesticides and anthelmintics.