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| NEFAZODONE HYDROCHLORIDE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 83366-66-9 |
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| EINECS NO. | ||
| FORMULA | C25H32ClN5O2·HCl | |
| MOL WT. | 506.47 | |
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H.S. CODE |
2934.90 | |
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TOXICITY |
Oral rat LD50: 980mg/kg | |
| SYNONYMS | Serzone; | |
| 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)- 3H-1,2,4- triazol- 3-one hydrochoride; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off-white crystalline powder | |
| MELTING POINT |
186 - 188 C |
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| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER |
Slightly soluble |
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| pH | ||
| VAPOR DENSITY |
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| AUTOIGNITION |
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| NFPA RATINGS | ||
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY |
Stable under ordinary conditions. |
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APPLICATIONS |
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| Nefazodone, derived from phenylpiperazine, is used as an antidepressant agent related with trazodone structurally. It is not a tri or tetra cyclic compounds which most antidepressants are specified with structurally. The hydrochloride salt of nefazodone is a white to off-white crystalline powder; melting point 186 - 188 C; slightly soluble in water; soluble in chloroform and propylene glycol; administered orally. The chemical designation is 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]- 5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4- triazol-3-one monohydrochloride. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
White to off-white crystalline powder | |
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ASSAY |
98.0 - 102.0% |
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RESIDUE ON IGNITION |
0.1% max |
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LOSS ON DRYING |
0.5% max |
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HEAVY METALS |
20ppm max |
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| TRANSPORTATION | ||
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| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 22/24-45 | ||
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