MEGLUMINE

PRODUCT IDENTIFICATION

CAS NO. 6284-40-8

N-METHYL-D-GLUCAMINE

EINECS NO. 228-506-9
FORMULA CH3NHCH2(CHOH)4CH2OH
MOL WT. 195.22

H.S. CODE

2922.19

TOXICITY

 

SYNONYMS 1-Deoxy-1-methylaminosorbitol; N-Methyl-d-glucamine;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT 128 - 132 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY  

AUTOIGNITION

350 C

NFPA RATINGS

Health: 0; Flammability: 0; Reactivity: 1

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION AND APPLICATIONS

Glucamine, 1-amino-1-deoxy-D-sorbitol, is an amine formed by reduction of glucosylamine or  glucose oxime. N-alkylated glucamines are prepared from D-glucose and relevant alkylamines. Meglumine is N-methyl glucamine, a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. It is a white crystalline powder; melting at 130 C. Meglumine is used in the preparation of certain radiopaque media such as diatrizoate meglumine and iodipamide meglumine. Meglumine is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. Excipients are combined also to support the active ingredients, so that the latter can be easily administered or absorbed in the body. Examples of meglumine-combined drugs are flunixin meglumine (non-steroidal anti-inflammatory drugs, used as a veterinary anti-inflammatory and analgesic) and meglumine antimoniate (antiprotozoal to treat leishmaniasis). Meglumine is used in ion-exchange resins to chelate boron ions selectively. N-alkyl glucamines are used in preparing functional surfactants and some solutions which are stable over a wide range of pH and ionic strength.
SALES SPECIFICATION

APPEARANCE

white powder

ASSAY

99.0% min

OPTICAL ROTATION

-15.5° ~ -17.5°

LOSS ON DRYING

0.5% max

TRANSPORTATION
PACKING 25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 24/25
EXAMPLES OF EXCIPIENT
Excipient

CAS RN

Acacia gum 9000-01-5
Calcium sulfate 7778-18-9
Carboxymethylcellulose Sodium 9004-32-4
Carrageenan gum 9000-07-1
Crospovidone 9003-39-8
1-Deoxy-1-(octylamino)-D-glucitol 23323-37-7
Dimethyl sulfoxide 67-68-5
Dioctyl sulfosuccinic acid and its salts  
Fosveset 193901-91-6
Gelatin 9000-70-8
Hydroxypropyl methylcellulose 9004-65-3
Karaya gum 9000-36-6
Laurocapram 59227-89-3
Meglumine 6284-40-8
Nonoxynol 26027-38-3
N-Stearoylglycine 158305-64-7
Octabenzone 1843-05-6
Octoxynol 9002-93-1
Phthaloyl chloride 88-95-9
Polipropene 9003-07-0
Poloxamer 106392-12-5
Polyethylene glycol ethers 25322-68-3
Propyleneglycol esters  
Sorbitol 50-70-4
Sucrose 57-50-1
Talc 14807-96-6
Taurodeoxycholic acid 516-50-7
Tragacanth 9000-65-1
Tricaprilin 538-23-8
Tromethamine 77-86-1