| CAS
NO. |
121-60-8 |
|
| EINECS
NO. |
204-485-1
|
| FORMULA |
C8H8ClNO3S |
| MOL
WT. |
233.67 |
|
H.S.
CODE
|
|
|
TOXICITY
|
Oral rat LD50:
>3200 mg/kg |
| SYNONYMS |
4-Acetamidobenzenesulphonyl chloride;
ASC; |
| N-Acetylsulfanilylchlorid (German); Cloruro de N-acetilsulfanililo
(Spanish); Chlorure de N-acétylsulfanilyle (French); |
| SMILES |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
tan
crystalline powder |
| MELTING POINT |
145 - 148 C |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Slightly soluble (soluble in benzene, chloroform and ether) |
| pH |
|
| VAPOR DENSITY |
8.1 |
| AUTOIGNITION |
|
| NFPA RATINGS |
Health: 1 Flammability: 0 Reactivity: 0 |
| REFRACTIVE
INDEX
|
|
| FLASH
POINT |
112
C |
| STABILITY |
Stable
under ordinary conditions. Moisture sensitive. |
|
APPLICATIONS
|
|
N-Acetylsulfanilyl chloride
is used in the preparation of sulfanilamide and its derivatives
which are intermediates to produce sulfa drugs.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
tan
crystalline powder |
|
ASSAY |
99.0%
min
|
| TRANSPORTATION |
| PACKING |
25kgs
in fiber drum |
| HAZARD CLASS |
8
(Packing Group: II) |
| UN
NO. |
3261 |
| OTHER
INFORMATION |
|
Hazard
Symbols: C, Risk Phrases: 34-37,
Safety Phrases: S:26-36/37/39-45 |
|
GENERAL
DESCRIPTION OF SULFONAMIDE
|
Sulfonamide is
an organic sulfur compounds containing the radical -SO2NH2 (the amides of
sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid
(PABA) which is needed in bacteria organisms as a substrate of the enzyme
dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF).
Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering
with the metabolic processes in bacteria that require PABA. They act as
antimicrobial agents by inhibiting bacterial growth and activity and called
sulfa drugs. They are used in the prevention and treatment of bacterial
infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug
includes;
- Topical
sulfonamides: sulfacetamide; silver sulfadiazine; mafenide; mafenide
acetate;
- Rapidly
absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine;
sulfamethoxazole;
- Hydrophylic sulfonamides: phtalylsulfacetamide;
phtalylsulfathiazole; sulfasalazine; sulfaguanidine;
- Long lasting
sulfonamides: sulfadoxine;
- Others:
sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol;
succinylsulfathiazole;
|