N,N'-CARBONYLDIIMIDAZOLE

PRODUCT IDENTIFICATION

CAS NO.

530-62-1; 128456-94-0

N,N'-CARBONYLDIIMIDAZOLE

EINECS NO. 208-488-9
FORMULA (C3H3N2)2CO
MOL WT. 162.15

H.S. CODE

 

TOXICITY

 

SYNONYMS 1,1'-Carbonylbis-1H-Imidazole; CDI;
1,1'-Carbonyldiimidazole; 1,1'-Carbonylbis-1H-imidazol (German); 1,1'-Carbonilbis-1H-imidazol (Spanish); 1,1'-carbonylbis-1H-imidazole (French); Diimidazol-1-yl ketone; N,N'-Carbonylbis(imidazole); 1-Oxomethylenebis(N-imidazole);
SMILES

 

CLASSIFICATION

COUPLING REAGENTS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT 117 - 122 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Decomposes
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 2; Flammability: 1; Reactivity:

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions.  Moisture sensitive.

APPLICATIONS

N,N'-Carbonyldiimidazole is a white crystals with a melting point of 116 C. It is hydrolyzed by water quickly. It is used as a coupling agent for the synthesis of peptides. When reacted with amino acids or peptide esters, it releases the imidazole group to couple the peptides. CDI is also a very reactive reagent in organic synthesis, mainly in converting alcohols and amines into esters, amides, ketones, and ureas. The reactivity is similar to acid chlorides for the activation of acids as imidazolides reagent. CDI undergoes reaction with peroxide to form the peroxycarboxylic acid and imidazole group can be reduced to form aldehydes from the carboxylic acid. CDI reagent is also used to make beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. CDI is a carbonyl-transfer reagent for the synthesis of various heterocycles.

CARBODIIMIDES

Product

CAS RN

N,N'-Dicyclohexylcarbodiimide

538-75-0

N,N'-Diphenylcarbodiimide 622-16-2

N,N'-Di-tert-butylcarbodiimide

691-24-7

N,N'-Diisopropylcarbodiimide

693-13-0

1,3-Di-p-tolylcarbodiimide

726-42-1

Bis(3-chloro-2-methylphenyl)carbodiimide 961-63-7
Bis(trimethylsilyl)carbodiimide 1000-70-0
Bis(o-tolylcarbodiimide) 1215-57-2

1-tert-Butyl-3-ethylcarbodiimide

1433-27-8

N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide

1892-57-5

Bis(2,6-diisopropylphenyl)carbodiimide 2162-74-5
Bis(2,6-diethylphenyl)carbodiimide 2162-75-6

N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate

2491-17-0

N-Cyclohexyl-N'-isopropylcarbodiimide 3496-83-1
N-Methyl-N'-phenylcarbodiimide 4172-91-2
1-Cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide 15580-20-8

1-(3-(Dimethylamino)propyl)-3-ethylcarbodiimide methiodide

22572-40-3

N,N'-Dicyclohexyl-N-methylcarbodiimidium iodide 36049-77-1
N-(2,2,6,6-Tetramethylpiperidyl-1-oxyl) N'-(cyclohexyl)carbodiimide 42249-40-1
1-Ethyl-3-(4-azonia-4,4-dimethylpentyl)carbodiimide 45024-77-9
Bis(2,4,6-triisopropyl-3-isocyanatophenyl)carbodiimide 68083-39-6
1-Phenyl-3-trimethylaminopropyl carbodiimide 79322-24-0
N-Cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide 86332-16-3
N-Cyclohexyl-N'-(1-pyrenyl)carbodiimide 98540-87-5
1-Ethyl-3-(3-dimethylaminoethyl)carbodiimide 141650-20-6
SALES SPECIFICATION

APPEARANCE

white powder

ASSAY

98.0% min

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 24/25
Price:
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