MOMETASONE FUROATE

PRODUCT IDENTIFICATION

CAS NO. 105102-22-5 (Base)
83919-23-7 (F
uroate)

MOMETASONE FUROATE 

EINECS NO.  
FORMULA C27H30Cl2O6
MOL WT. 521.44

H.S. CODE

 

TOXICITY

 

SYNONYMS Elocon; 

9a,21-Dichloro-11b,17-dihydroxy-16a -methylpregna-1,4-diene-3,20-dione 17-(2-furoate);

SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White crystalline powder
MELTING POINT 220 C (decomposes)
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION  & APPLICATIONS

Corticosteroid is a synthetic or naturally occurring 21-carbon steroid structure substances with four fused rings and vary functional branches attached to the ring system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid refers to these three groups that contain a hydrogenated cyclopentano perhydro phenanthrene ring system. In restricted context for medical usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal cortex in response to physiological carbohydrate metabolism. According to their predominant biologic activity, they are divided into two major groups: glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to regulate carbohydrate, lipid, and protein metabolism and inhibit the release of ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and the microcirculation, participate in the maintenance of arterial blood pressure, increase gastric secretion, alter connective tissue response to injury, impede cartilage production, inhibit inflammatory, allergic, and immunologic responses, invoke shrinkage of lymphatic tissue, reduce the number of circulating lymphocytes, and affect the functions of the central nervous system. In humans, the most important ones are cortisol, cortisone, and corticosterone. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Aldosterone plays a role also in promoting tissue repair. Spironolactone is the aldosterone antagonist called potassium-sparing diuretic used in the treatment of hypertension. Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses.
  • Glucocorticoid Receptor Agonists
    • Dexamethasone
    • Triamcinolone
    • Hydrocortisone
    • Prednisone
  • Glucocorticoid Receptor Antagonists
    • Mifepristone
    • Onapristone
  • Mineralocorticoid Receptor Agonists
    • Aldosterone
  • Mineralocorticoid Receptor Antagonists
    • Spironolactone
    • Eplerenone

Mometasone, a synthetic analogue of prednisolone, is used in for the relief of inflammation and pruritus in corticosteroid-responsive dermatoses. The furoate of mometasone is a white to off-white crystalline powder; insoluble in water; slightly soluble in alcohol; soluble in tetrahydrofuran, acetone and chloroform; melting point 220 C. The chemical designation 9a,21-Dichloro-11b,17-dihydroxy-16a -methylpregna-1,4-diene-3,20-dione 17-(2-furoate).

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

Complies

ASSAY

97.0 - 103.0%

OPTICAL ROTATION

+50° ~ +55°

RELATED SUBSTANCE

Complies

LOSS ON DRYING

0.5% max

TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 36/37/38, Safety Phrases: 26-36