ISOSORBIDE

PRODUCT IDENTIFICATION

CAS NO.

652-67-5

ISOSORBIDE

EINECS NO. 211-492-3
FORMULA C6H10O4
MOL WT. 146.14

H.S. CODE

2932.99

TOXICITY

 

SYNONYMS
D-1,4:3,6-Dianhydroglucitol; Devicoran; 
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

Yellow to Greenish Solidified Mass

MELTING POINT 61 - 63 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions. Hygroscopic.

APPLICATIONS

Isosorbide is a bicyclic ether derivative of glucitol. The nitric acid esters of isosorbide are used as osmotic diuretic to reduce intraocular pressure with effects on both arteries and veins and to treat coronary insufficiency and angina pectoris. The monoester is a white crystalline powder; melting point  140 C; freely soluble in water, alcohol and chloroform. The diester is a white crystalline powder; melting point  70 C; sparingly soluble in water; soluble in organic solvents; administered sublingually and orally. Eesters are explosive.. It should be diluted (25 - 40%) with lactose or mannitol for transportation. Chemical designation is 1,4:3,6-dianhydro-D-glucitol mono (di) nitrate.
SALES SPECIFICATION

APPEARANCE

Yellow to Greenish Solidified Mass

PURITY (HPLC)

98.0% min

SOLIDIFYING POINT

59 C

TRANSPORTATION
PACKING
25kgs in Drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION