ISOSORBIDE DINITRATE

PRODUCT IDENTIFICATION

CAS NO. 87-33-2

ISOSORBIDE DINITRATE

EINECS NO. 201-740-9
FORMULA C6H8N2O8
MOL WT. 236.14

H.S. CODE

3003.90

TOXICITY

SYNONYMS 1,4:3,6-Dianhydro-D-glucitol dinitrate;
Dinitrato de isosorbida; Dinitrate d'isosorbide;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 69 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions. Hygroscopic.

APPLICATIONS

Isosorbide is a bicyclic ether derivative of glucitol. The nitric acid esters of isosorbide are used as osmotic diuretic to reduce intraocular pressure with effects on both arteries and veins and to treat coronary insufficiency and angina pectoris. The monoester is a white crystalline powder; melting point  140 C; freely soluble in water, alcohol and chloroform. The diester is a white crystalline powder; melting point  70 C; sparingly soluble in water; soluble in organic solvents (acetone, alcohol, ether); administered sublingually and orally. Eesters are explosive. It should be diluted (25 - 40%) with lactose or mannitol for transportation. Chemical designation is 1,4:3,6-dianhydro-D-glucitol mono (di) nitrate.
SALES SPECIFICATION (USP)

APPEARANCE

white crystalline powder

PURITY

98.0% min (Lactose 60% - 75%)

MELTING POINT

69 C

SULFATED ASH

0.1% max

HEAVY METALS

20ppm max

TRANSPORTATION
PACKING
25kgs in Drum
HAZARD CLASS 4.1 (Packing Group: II)
UN NO. 2907
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 5-22, Safety Phrases: 36