ISOPROTERENOL HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO. 7683-59-2 (Base)
51-30-9 (Hydrochloride)

ISOPROTERENOL

EINECS NO. 231-687-7, 200-089-8
FORMULA (HO)2C6H3CH(OH)CH2NHCH(CH3)2·HCl
MOL WT. 247.72

H.S. CODE

 

TOXICITY

 

SYNONYMS Isoprenaline Hydrochloride; Isopropydrine HCl;
3,4-Dihydroxy-alpha-((isopropylamino)methyl)-benzyl alcohol hydrochloride; 4-(1-Hydroxy-2-((methylethyl)amino)ethyl)-1,2-benzenediol hydrochloride; Aludrine hydrochloride; Isopropylarterenol hydrochloride; Isopropylnorepinephrine-hydrochloride; Isoproterenol monohydrochloride;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 165 - 170 C (Decomposes)
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Isoproterenol is a synthetic sympathomimetic amine having powerful bronchodilator and cardiac stimulant actions. It, is structurally related to norepinephrine but acts almost exclusively on beta-receptors. It may also be used in the management of shock, treatment and prevention of cardiac standstill and arrhythmias, and treatment of bronchospasm during anesthesia. It is chemcially described as 3,4-Dihydroxy-alpha-[(isopropylamino) methyl] benzyl alcohol. The hydrochloride salt of isoproterenol is a white or off white crystalline powder; soluble in water; melting point 170 - 171 C; administered by oral inhalation, sublingually, and parenterally. The sulfate salt of isoproterenol is administered by oral inhalation.

Tyramine [4-(2-Aminoethyl)phenol] is a monoamine compound of 4-hydroxy phenethylamine. It is derived from tyrosine, an amino acid (protein building block) that is the precursor of norepinephrine. It, through its effect on neurotransmitters, may affect several health conditions, including Parkinson's disease, depression, alcohol withdrawal support, and Phenylketonuria. (PKU). Tyramine is naturally found in plant and animal tissues, certain cheeses and ergot or produced synthetically. It is metabolized by monoamine oxidase. Tyramine or its derivatives can be used in pharmaceutical industry such as:

  • Sympathomimetic or adrenergic drugs themselves or intermediate of them.
  • Intermediate for bezafibrate used in the treatment of high cholesterol levels.
  • Determination of peroxide activity in the fluorescence enzyme immunoassay for insulin.
  • False transmitter.

Tryptamine [3-(2-Aminoethyl)indole] is a biologically important monoamine compound derived  by the decarboxylation of tryptophan, indole side chain amino acid. In addition to its function to build the structure of protein, tryptophan is a precursor for neurotransmitter and neurohormone. Tryptamine (biological monoamine) effects vasoconstriction by causing the release of norepinephrine at postganglionic nerve endings. Several mental disorders and health conditions are explained as due to either an excess or deficiency of monoamines. There are many natural tryptamines in both animal and plant as well as synthetics modified by chemical constituents and substituted at appropriate positions in the motif. Common tryptamine class compounds include;

  • Bufotenine (CAS #: 487-93-4): (5-Hydroxy-N,N-dimethyltryptamine, pressor agent, epinephrine-like.
  • DMT (CAS #: 61-50-7): N,N-Dimethyltryptamine, a psychedelic and hallucinogenic.
  • Luzindole (CAS #: 117946-91-5): N-Acetyl-2-benzyltryptamine
  • Melatonin (CAS #: 73-31-4, 8041-44-9): N-Acetyl-5-methoxytryptamine, biological clock hormone.
  • Psilocin: 4-Hydroxy-N,N-dimethyltryptamine.
  • Psilocybin (CAS #: 520-52-5): 4-Phosphoryloxy-N,N-dimethyltryptamine, a hallucinogenic.
  • Serotonin (CAS #: 50-67-9): 5-Hydroxytryptamine, a vasoconstrictor.
  • Sumatriptan( CAS #: 103628-46-2) 4-Hethylaminosulfonyl-N,N-dimethyltryptamine, selective serotonin antagonist used in the treatment of migraine headache.
SALES SPECIFICATION

APPEARANCE

white crystalline powder

IDENTIFICATION

Complies Test A,B

ASSAY

98.5% min

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.1% max

HEAVY METALS

10ppm max

pH

4.5 - 5.5

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36
ISOPROTERENOL  MOLECULES

PRODUCT

CAS RN.

Pronetalol hydrochloride

51-02-5

Dichloroisoproterenol hydrochloride 51-29-6
Isoproterenol hydrochloride 51-30-9
Levisoprenaline 51-31-0
Pronetalol 54-80-8
Isoproterenol bitartrate 59-60-9
Dichloroisoproterenol 59-61-0
DL-Isoproterenol sulfate 114-45-4
Isadrine 149-53-1
Isoproterenol sulfate 299-95-6
Isoproterenol hydrochloride 949-36-0
Metiprenaline [INN] 1212-03-9
D-Isoprenaline 2964-04-7

Clorprenaline

3811-25-4

1-Phenyl-2-isopropylaminoethanol

4164-21-0
Desoxyisoprenaline hydrochloride 5178-52-9
l-Isoprenaline chloride 5984-95-2
Isoproterenol sulfate 6700-39-6
Isoproterenol 7683-59-2
D-Isoproterenol bitartrate 14638-70-1
3-O,4-O-Diacetylisoproterenol 35553-62-9
Isolevin 40915-50-2
Di-4-toluoylisoproterenol 47733-27-7
Hydroxybenzylisoproterenol 64532-93-0
Dipivaloylisoproterenol 65114-85-4

4-Chloroisoprenaline

77145-71-2
3-O,4-O-Dibenzoylisoproterenol 80186-86-3

2-(3,4-Diacetoxyphenyl)-2-chloro-N-isopropyl-1-ethanamine

98634-91-4
PRICES

Click to open the table

 

Click to close the table